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6-Methoxytricin

🥰Excellent
Catalog No. T10183Cas No. 76015-42-4

6-Methoxytricin, a flavonoid isolated from Centella asiatica, is an inhibitor of aldose reductase (AR) and advanced glycosylation end-products (AGE), and inhibits T-cell proliferation and activation in biologic cells.

6-Methoxytricin

6-Methoxytricin

🥰Excellent
Purity: 99.4%
Catalog No. T10183Cas No. 76015-42-4
6-Methoxytricin, a flavonoid isolated from Centella asiatica, is an inhibitor of aldose reductase (AR) and advanced glycosylation end-products (AGE), and inhibits T-cell proliferation and activation in biologic cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$65-In Stock
2 mg$92-In Stock
5 mg$150In StockIn Stock
10 mg$267-In Stock
1 mL x 10 mM (in DMSO)$200-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.4%
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COA CNMR HNMR HPLC

Product Introduction

Bioactivity
Description
6-Methoxytricin, a flavonoid isolated from Centella asiatica, is an inhibitor of aldose reductase (AR) and advanced glycosylation end-products (AGE), and inhibits T-cell proliferation and activation in biologic cells.
Targets&IC50
AR:30.29 μM, AGE:134.88 μM
In vitro
6-Methoxytricin has a significant inhibitory effect on T cell proliferation induced by concanavalin A (Con A), with an IC50 value of 1.4 μM [2].
Chemical Properties
Molecular Weight360.31
FormulaC18H16O8
Cas No.76015-42-4
SmilesO=C1C=C(OC2=CC(O)=C(OC)C(O)=C12)C=3C=C(OC)C(O)=C(OC)C3
Relative Density.1.461 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (138.77 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7754 mL13.8769 mL27.7539 mL138.7694 mL
5 mM0.5551 mL2.7754 mL5.5508 mL27.7539 mL
10 mM0.2775 mL1.3877 mL2.7754 mL13.8769 mL
20 mM0.1388 mL0.6938 mL1.3877 mL6.9385 mL
50 mM0.0555 mL0.2775 mL0.5551 mL2.7754 mL
100 mM0.0278 mL0.1388 mL0.2775 mL1.3877 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ARAldose reductaseAGE6-Methoxytricin6Methoxytricin6 Methoxytricin
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