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6-Methoxytricin

Name: 6-Methoxytricin
Brand: TargetMol
SKU: T10183
Price: 65 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10183Cas No. 76015-42-4

6-Methoxytricin, a flavonoid isolated from Centella asiatica, is an inhibitor of aldose reductase (AR) and advanced glycosylation end-products (AGE), and inhibits T-cell proliferation and activation in biologic cells.

6-Methoxytricin

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Purity: 99.4%

Catalog No. T10183Cas No. 76015-42-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$65	-	In Stock
2 mg	$92	-	In Stock
5 mg	$150	In Stock	In Stock
10 mg	$267	-	In Stock
1 mL x 10 mM (in DMSO)	$200	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.4%

Appearance:Solid

Color:Yellow

Resource Download

COA CNMR HNMR HPLC

Product Introduction

Bioactivity

Description	6-Methoxytricin, a flavonoid isolated from Centella asiatica, is an inhibitor of aldose reductase (AR) and advanced glycosylation end-products (AGE), and inhibits T-cell proliferation and activation in biologic cells.
Targets&IC50	AGE:134.88 μM, AR:30.29 μM
In vitro	6-Methoxytricin has a significant inhibitory effect on T cell proliferation induced by concanavalin A (Con A), with an IC50 value of 1.4 μM [2].

Chemical Properties

Molecular Weight	360.31
Formula	C₁₈H₁₆O₈
Cas No.	76015-42-4
Smiles	O=C1C=C(OC2=CC(O)=C(OC)C(O)=C12)C=3C=C(OC)C(O)=C(OC)C3
Relative Density.	1.461 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (138.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7754 mL	13.8769 mL	27.7539 mL	138.7694 mL
5 mM	0.5551 mL	2.7754 mL	5.5508 mL	27.7539 mL
10 mM	0.2775 mL	1.3877 mL	2.7754 mL	13.8769 mL
20 mM	0.1388 mL	0.6938 mL	1.3877 mL	6.9385 mL
50 mM	0.0555 mL	0.2775 mL	0.5551 mL	2.7754 mL
100 mM	0.0278 mL	0.1388 mL	0.2775 mL	1.3877 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc