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DL-Borneol

Catalog No. T77796 CAS 507-70-0

Synonyms: (endo)-Borneol, Borneol, (±)-Borneol

DL-Borneol ((endo)-Borneol) is a small molecule extracted from traditional Chinese medicine (TCM). It is an orally bioadjuvant that improves drug delivery to the brain and is commonly used as an adjuvant ingredient in TCM for the treatment of cardio-cerebral vascular diseases.

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DL-Borneol, CAS 507-70-0

Pack Size	Availability	Price/USD
50 mg	In stock	$ 40.00
100 mg	In stock	$ 57.00
500 mg	In stock	$ 188.00

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Purity: 98.61%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	DL-Borneol ((endo)-Borneol) is a small molecule extracted from traditional Chinese medicine (TCM). It is an orally bioadjuvant that improves drug delivery to the brain and is commonly used as an adjuvant ingredient in TCM for the treatment of cardio-cerebral vascular diseases.
Targets&IC50	26S:157±19 μM, 20S:118.8±15.7 μM
In vitro	In vitro, Borneol enhances the intracellular accumulation of Rho123 and facilitates the transport of P-gp substrates across the blood-brain barrier (BBB). Additionally, it downregulates the expression of mdr1a mRNA and P-gp. Borneol activates NF-κB, and the inhibition of NF-κB with MG132 and SN50 attenuates the reduction in P-gp induced by Borneol. Treatment with 10 μg/mL and 20 μg/mL Borneol transiently increases the phosphorylation of IκB expression at 30 min post-treatment. Furthermore, Borneol treatment leads to a decrease in P-gp expression in brain microvascular endothelial cells (BMECs)[1].
In vivo	Borneol significantly counteracts the process of epileptogenesis in PTZ-kindled mice. Borneol-treated animals show amelioration of biochemical alterations induced by PTZ kindling, as evidenced by decreased lipid peroxidation (LPO) and increased levels of superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT). The distinct neuronal damage observed in the kindled group is suppressed by Borneol. Additionally, Borneol reduces the levels of GFAP, as indicated by reduced immunostaining[3]. The pharmacokinetic traits of Borneol are significantly affected by the pathological damages of ischemia-reperfusion, and there are components in Xingnaojing that inhibit the absorption of Borneol[2].

Synonyms	(endo)-Borneol, Borneol, (±)-Borneol
Molecular Weight	154.25
Formula	C10H18O
CAS No.	507-70-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (259.32 mM), Sonication is recommended.

H2O: <0.1 mg/mL (Insoluble)

References and Literature

1. Fan X, et al. Borneol Depresses P-Glycoprotein Function by a NF-κB Signaling Mediated Mechanism in a Blood Brain Barrier in Vitro Model. Int J Mol Sci. 2015 Nov 18;16(11):27576-88. 2. Xu P, et al. Comparative pharmacokinetics of borneol in cerebral ischemia-reperfusion and sham-operated rats. J Zhejiang Univ Sci B. 2014 Jan;15(1):84-91. 3. Tambe R, et al. Antiepileptogenic effects of borneol in pentylenetetrazole-induced kindling in mice. Naunyn Schmiedebergs Arch Pharmacol. 2016 May;389(5):467-75. 4. Luo M,et al. Borneol exerts its antipruritic effects by inhibiting TRPA1 and activating TRPM8. J Ethnopharmacol. 2024 Mar 25;322:117581. 5. Chang TL,et al. Borneol and Luteolin from Chrysanthemum morifolium Regulate Ubiquitin Signal Degradation. J Agric Food Chem. 2018 Aug 8;66(31):8280-8290.

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Keywords

DL-Borneol 507-70-0 Membrane transporter/Ion channel Metabolism Neuroscience Endogenous Metabolite GABA Receptor (endo)-Borneol Borneol (±)-Borneol inhibitor inhibit

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