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IRF1-IN-2
🥰Excellent
Catalog No. T203076Cas No. 708245-32-3
Alias IRF1-IN2
IRF1-IN-2 is a small molecule inhibitor of interferon regulatory factor 1 (IRF1) that functions by reducing the binding affinity of IRF1 for the caspase-1 (CASP1) gene promoter. this inhibition subsequently suppresses critical cell death signaling pathways, such as pyroptosis, and provides robust protection against ionizing radiation-induced skin inflammatory damage in preclinical models.
IRF1-IN-2
🥰Excellent
Purity: 99.85%
Catalog No. T203076Alias IRF1-IN2Cas No. 708245-32-3
IRF1-IN-2 is a small molecule inhibitor of interferon regulatory factor 1 (IRF1) that functions by reducing the binding affinity of IRF1 for the caspase-1 (CASP1) gene promoter. this inhibition subsequently suppresses critical cell death signaling pathways, such as pyroptosis, and provides robust protection against ionizing radiation-induced skin inflammatory damage in preclinical models.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $36 | In Stock | |
| 50 mg | $55 | In Stock | |
| 100 mg | $80 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Purity:99.85%
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Product Introduction
Bioactivity
Chemical Properties
| Description | IRF1-IN-2 is a small molecule inhibitor of interferon regulatory factor 1 (IRF1) that functions by reducing the binding affinity of IRF1 for the caspase-1 (CASP1) gene promoter. this inhibition subsequently suppresses critical cell death signaling pathways, such as pyroptosis, and provides robust protection against ionizing radiation-induced skin inflammatory damage in preclinical models. |
| In vitro | Pretreatment of irradiated HaCaT cells, HELF and WS1 cells with IRF1-IN-2 (20 μM, 12 h) reduced the recruitment of IRF1 to the CASP1 promoter in HaCaT cells (20 Gy) and also attenuated IRF1 activation induced by NSP-10 plasmid transfection in HELF and WS1 cells. [1] |
| In vivo | Methods: IRF1-IN-2 (100 μg/d, subcutaneous injection, irradiated every other day) was administered to mice with inflammatory skin lesions induced by 35 Gy radiation, and its effects were observed. Results: IRF1-IN-2 has a potential protective effect against inflammatory skin lesions induced by 35 Gy radiation in mice. [1] |
| Synonyms | IRF1-IN2 |
| Molecular Weight | 360.43 |
| Formula | C18H20N2O4S |
| Cas No. | 708245-32-3 |
| Smiles | O=C(NC1=CC=C(C=C1)S(=O)(=O)N2CCCC2)C=3C=CC=CC3OC |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 105 mg/mL (291.32 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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