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IRF1-IN-2
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Catalog No. T203076Cas No. 708245-32-3
Alias IRF1-IN2
IRF1-IN-2 is a small molecule inhibitor of interferon regulatory factor 1 (IRF1) that functions by reducing the binding affinity of IRF1 for the caspase-1 (CASP1) gene promoter. this inhibition subsequently suppresses critical cell death signaling pathways, such as pyroptosis, and provides robust protection against ionizing radiation-induced skin inflammatory damage in preclinical models.
IRF1-IN-2
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Purity: 99.85%
Catalog No. T203076Alias IRF1-IN2Cas No. 708245-32-3
IRF1-IN-2 is a small molecule inhibitor of interferon regulatory factor 1 (IRF1) that functions by reducing the binding affinity of IRF1 for the caspase-1 (CASP1) gene promoter. this inhibition subsequently suppresses critical cell death signaling pathways, such as pyroptosis, and provides robust protection against ionizing radiation-induced skin inflammatory damage in preclinical models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $36 | - | In Stock | |
| 50 mg | $55 | - | In Stock | |
| 100 mg | $80 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.85%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | IRF1-IN-2 is a small molecule inhibitor of interferon regulatory factor 1 (IRF1) that functions by reducing the binding affinity of IRF1 for the caspase-1 (CASP1) gene promoter. this inhibition subsequently suppresses critical cell death signaling pathways, such as pyroptosis, and provides robust protection against ionizing radiation-induced skin inflammatory damage in preclinical models. |
| In vitro | Pretreatment of irradiated HaCaT cells, HELF and WS1 cells with IRF1-IN-2 (20 μM, 12 h) reduced the recruitment of IRF1 to the CASP1 promoter in HaCaT cells (20 Gy) and also attenuated IRF1 activation induced by NSP-10 plasmid transfection in HELF and WS1 cells. [1] |
| In vivo | Methods: IRF1-IN-2 (100 μg/d, subcutaneous injection, irradiated every other day) was administered to mice with inflammatory skin lesions induced by 35 Gy radiation, and its effects were observed. Results: IRF1-IN-2 has a potential protective effect against inflammatory skin lesions induced by 35 Gy radiation in mice. [1] |
| Synonyms | IRF1-IN2 |
| Molecular Weight | 360.43 |
| Formula | C18H20N2O4S |
| Cas No. | 708245-32-3 |
| Smiles | O=C(NC1=CC=C(C=C1)S(=O)(=O)N2CCCC2)C=3C=CC=CC3OC |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 105 mg/mL (291.32 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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