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FOLR1 Protein, Rhesus macaque, Recombinant (His)

Catalog No. TMPJ-00148
Synonyms: FR-alpha, Adult folate-binding protein, Ovarian tumor-associated antigen MOv18, FOLR1, Folate receptor, Folate receptor 1, FBP, FR-α, Folate receptor α, Folate receptor alpha

Folate receptor alpha(FOLR) belongs to the folate receptor family, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
FOLR1 Protein, Rhesus macaque, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 102.00
50 μg 5 days $ 310.00
500 μg 5 days $ 2,590.00
1 mg 5 days $ 3,880.00
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Biological Description
Technical Params
Product Properties
Description Folate receptor alpha(FOLR) belongs to the folate receptor family, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.
Species Rhesus Macaque
Expression System Human Cells
Tag C-6His
Accession Number F7BP60
Synonyms FR-alpha, Adult folate-binding protein, Ovarian tumor-associated antigen MOv18, FOLR1, Folate receptor, Folate receptor 1, FBP, FR-α, Folate receptor α, Folate receptor alpha
Amino Acid Arg25-Ser234
Construction Recombinant Rhesus Macaque Folate receptor alpha is produced by our Mammalian expression system and the target gene encoding Arg25-Ser234 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 28-38 kDa, reducing conditions
Endotoxin Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background Folate receptor alpha(FOLR) belongs to the folate receptor family, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.

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Keywords

FOLR1 Protein, Rhesus macaque, Recombinant (His) FR-alpha Adult folate-binding protein Ovarian tumor-associated antigen MOv18 FOLR1 Folate receptor Folate receptor 1 FBP FR-α FOLR 1 FOLR-1 Folate receptor α Folate receptor alpha recombinant recombinant-proteins proteins protein

 

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