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Brincidofovir
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Catalog No. TQ0095Cas No. 444805-28-1
Alias HDP-CDV, CMX001
Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir. It has enhanced activity compared to CDV against certain adenoviruses, herpesviruses, and orthopoxviruses.
Brincidofovir
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Purity: 99.62%
Catalog No. TQ0095Alias HDP-CDV, CMX001Cas No. 444805-28-1
Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir. It has enhanced activity compared to CDV against certain adenoviruses, herpesviruses, and orthopoxviruses.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $48 | In Stock | In Stock | |
| 5 mg | $115 | In Stock | In Stock | |
| 10 mg | $173 | In Stock | In Stock | |
| 25 mg | $348 | In Stock | In Stock | |
| 50 mg | $522 | In Stock | In Stock | |
| 100 mg | $669 | - | In Stock | |
| 200 mg | $953 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.62%
Appearance:Solid
Color:White
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Product Introduction
Brincidofovir AI Summary
Brincidofovir exhibits potent antiviral activities against a range of viruses, including Human Cytomegalovirus (HCMV), Mouse Cytomegalovirus (MCMV), Vaccinia virus (Copenhagen and WR strains), Cowpox virus (Brighton and Brighton Red strains), and Ectromelia virus. The compound is particularly effective in human foreskin fibroblast (HFF) cells, with EC50 values as low as 0.9 nM for HCMV and up to 1100.0 nM for Vaccinia virus WR. It also shows activity in BALB/c mouse models and pregnant guinea pigs, leading to significant reductions in viral DNA levels and viral-induced mortality, alongside improvements in pregnancy outcomes.
Brincidofovir has demonstrated cytotoxicity against HFF cells with a CC50 of 31000.0 nM and against BSC1 cells with a CC50 of 25300.0 nM. Its selectivity indices, reflecting the ratio of CC50 to EC50, range impressively high in several contexts, such as 313.0 for Vaccinia virus Copenhagen and 125.0 for Cowpox virus Brighton Red, suggesting good therapeutic margins.
Metabolic stability studies show that Brincidofovir has variable stability across different systems, including 83.3% stability in human liver S9 fractions at 1 µM after 90 minutes. Pharmacokinetic data from human trials indicate a Tmax of 7 hours and a dose-dependent half-life, ranging from 6.15 hours at 0.025 mg/kg to 32.7 hours at 1.5 mg/kg.
The compound thus holds promise for the development of antiviral therapies due to its potent activity, favorable selectivity indices, and promising pharmacokinetic profile..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir. It has enhanced activity compared to CDV against certain adenoviruses, herpesviruses, and orthopoxviruses. |
| Targets&IC50 | Anti-CMV (in PDA at 7 dpi):5.5 nM (EC50) |
| Synonyms | HDP-CDV, CMX001 |
| Molecular Weight | 561.69 |
| Formula | C27H52N3O7P |
| Cas No. | 444805-28-1 |
| Smiles | C([C@H](OCP(OCCCOCCCCCCCCCCCCCCCC)(=O)O)CO)N1C(=O)N=C(N)C=C1 |
| Relative Density. | 1.17 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | 0.1 M NaOH: 20 mg/mL (35.61 mM), Sonication is recommended.  0.1M NaOH: 29 mg/mL (51.63 mM) DMSO: 1 mg/mL (1.78 mM), when pH is adjusted to 6 with NaOH. Heating to 50℃ is recommended. H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/0.1 M NaOH/0.1M NaOH
0.1 M NaOH/0.1M NaOH
0.1M NaOH
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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