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Anti-Fc gamma R1 Antibody (H22) is a humanized monoclonal antibody targeting the high-affinity IgG receptor Fc gamma RI (CD64). This product binds specifically to the extracellular domain of CD64 at a site distinct from the natural IgG Fc-binding site, allowing it to maintain binding activity in the presence of physiological IgG concentrations. By targeting antigens to CD64 on the surface of myeloid cells (such as monocytes and macrophages), the antibody mediates efficient antigen internalization, processing, and presentation, significantly enhancing in vivo antibody immune responses.

| Description | Anti-Fc gamma R1 Antibody (H22) is a humanized monoclonal antibody targeting the high-affinity IgG receptor Fc gamma RI (CD64). This product binds specifically to the extracellular domain of CD64 at a site distinct from the natural IgG Fc-binding site, allowing it to maintain binding activity in the presence of physiological IgG concentrations. By targeting antigens to CD64 on the surface of myeloid cells (such as monocytes and macrophages), the antibody mediates efficient antigen internalization, processing, and presentation, significantly enhancing in vivo antibody immune responses. |
| In vitro | Anti-Fc gamma R1 Antibody binds human CD64 on monocytes/neutrophils with high affinity. Targeting an epitope outside the Fc-binding pocket, it captures antigens even under IgG saturation and triggers rapid internalization for MHC-mediated presentation [1]. |
| In vivo | In transgenic mice expressing human FcγRI (CD64), systemic administration of antigen conjugated to Anti-Fc gamma R1 Antibody increases specific antibody production 100-1000 fold compared to non-targeted antigens. This treatment significantly raises antigen-specific IgG and IgM titers, confirming that targeting CD64 on myeloid cells bypasses immune clearance and promotes potent humoral immunity [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | FcgammaR1 |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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