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SHU 9119 acetate

Name: SHU 9119 acetate
Brand: TargetMol
SKU: T16879L
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16879L

Alias SHU 9119 acetate (168482-23-3 free base)

SHU 9119 acetate is a well-known antagonist of human melanocortin 3 and 4 (hMC3R, hMC4R) receptors and a partial hMC5R agonist. The IC50 values of human MC3R, MC4R and MC5R is 0.23, 0.06, and 0.09 nM respectively.

SHU 9119 acetate

🥰Excellent

Purity: 99.8%

Catalog No. T16879LAlias SHU 9119 acetate (168482-23-3 free base)

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	In Stock	In Stock
5 mg	$383	In Stock	In Stock
10 mg	$575	In Stock	In Stock
25 mg	$923	In Stock	In Stock
50 mg	$1,260	In Stock	-
1 mL x 10 mM (in DMSO)	$647	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.8%

Appearance:Solid

Color:White

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COA HPLC MS

Product Introduction

Bioactivity

Description	SHU 9119 acetate is a well-known antagonist of human melanocortin 3 and 4 (hMC3R, hMC4R) receptors and a partial hMC5R agonist. The IC50 values of human MC3R, MC4R and MC5R is 0.23, 0.06, and 0.09 nM respectively.
Targets&IC50	MC5R (human):0.09 nM, MC4R (human):0.06 nM, MC3R (human):0.23 nM
In vivo	Compared with control, blocking CNS-Mcr by chronic intracerebroventricular infusion of SHU9119 (24 nmol/d for 7 days) increases food intake in ad libitum-fed rats. Weight gain of SHU9119 treated rats is significantly higher than control. SHU9119 treatment effectively increases metabolic efficiency. SHU9119 markedly increases mRNA levels of genes promoting lipogenesis and TAG storage in adipocytes, including stearoyl-CoA desaturase-1, lipoprotein lipase, acetyl-CoA carboxylase α, and fatty acid synthase. SHU9119 increases food intake (+30%) and body fat (+50%) and decreases EE by reduction in fat oxidation (?42%). Furthermore, SHU9119 impairs the uptake of VLDL-TG by BAT. In line with this, SHU9119 decreases uncoupling protein-1 levels in BAT (?60%) and induces large intracellular lipid droplets, indicative of severely disturbed BAT activity.
Synonyms	SHU 9119 acetate (168482-23-3 free base)

Chemical Properties

Molecular Weight	1134.29
Formula	C₅₆H₇₅N₁₅O₁₁
Smiles	CCCC[C@@H](C(N[C@H]1CC(NCCCC[C@@H](C(N)=O)NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC1=O)CC2=CNC=N2)=O)CC3=CC4=CC=CC=C4C=C3)=O)CCCNC(N)=N)=O)CC5=CNC6=C5C=CC=C6)=O)=O)=O)NC(C)=O.CC(O)=O
Relative Density.	no data available
Sequence	Ac-Nle-DL-Asp(1)-DL-His-D-2Nal-Arg-Trp-Lys(1)-NH2
Sequence Short	XDHXRWK

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (48.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8816 mL	4.4080 mL	8.8161 mL	44.0804 mL
5 mM	0.1763 mL	0.8816 mL	1.7632 mL	8.8161 mL
10 mM	0.0882 mL	0.4408 mL	0.8816 mL	4.4080 mL
20 mM	0.0441 mL	0.2204 mL	0.4408 mL	2.2040 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc