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Tetracycline

Name: Tetracycline
Brand: TargetMol
SKU: T0912L
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0912LCas No. 60-54-8

Alias Tetracyclinum, Tetracyclin, Deschlorobiomycin

Tetracycline is an orally active broad-spectrum antibiotic that exhibits inhibitory activity against various Gram-positive and Gram-negative bacteria, as well as Chlamydia, Mycoplasma, and Rickettsia. It is commonly used in anti-infection research and can also be used to induce tumor regression based on BCR-ABL gene silencing.

Tetracycline

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Purity: 98.18%

Catalog No. T0912LAlias Tetracyclinum, Tetracyclin, DeschlorobiomycinCas No. 60-54-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock
5 g	$44	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.18%

Appearance:solid

Color:White

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COA LCMS HNMR

Product Introduction

Tetracycline AI Summary

Tetracycline is a multifaceted bioactive agent exhibiting significant antibacterial and antimicrobial properties across a wide range of bacterial strains, including methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella enterica, and Helicobacter pylori, among others. The compound shows minimum inhibitory concentrations (MIC) varying from 0.25 µg/mL to greater than 256.0 µg/mL, depending on the specific bacterial strain and resistance profile. Moreover, Tetracycline demonstrates a robust activity against multidrug-resistant and extended-spectrum beta-lactamase (ESBL)-producing bacteria. In addition to inhibiting bacterial growth, it also exhibits bioactivity against fungal strains and antimalarial activity against Plasmodium species. The compound's effectiveness extends to both Gram-positive and Gram-negative bacteria, including strains associated with hospital-acquired infections and those exhibiting resistance mechanisms involving efflux pumps such as AcrAB-TolC. Pharmacokinetic profiles indicate that Tetracycline has a high fraction absorbed and moderate bioavailability, with good distribution characteristics in the body as reflected by volume of distribution (Vdss) and clearance (CL) rates. It shows pharmacodynamic efficacy in animal models against bacterial and parasitic infections, highlighting its potential for clinical applications. Additionally, Tetracycline exhibits weak inhibitory activity on certain human liver transporters like BSEP and demonstrates interactions with a range of human and rat receptors, enzymes, and transporters, suggesting a broad spectrum of physiological effects. However, its potential for liver toxicity and specific cytotoxic effects against human cell lines are areas requiring careful consideration. Overall, Tetracycline holds promise as a broad-spectrum antimicrobial agent with potential applications in treating complex bacterial infections, particularly those resistant to standard antibiotics. Further investigations into its pharmacodynamics, safety profile, and clinical efficacy are warranted to fully realize its therapeutic potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tetracycline is an orally active broad-spectrum antibiotic that exhibits inhibitory activity against various Gram-positive and Gram-negative bacteria, as well as Chlamydia, Mycoplasma, and Rickettsia. It is commonly used in anti-infection research and can also be used to induce tumor regression based on BCR-ABL gene silencing.
Targets&IC50	HaCaT cells:8 μM, CCRF-CEM cells:40.5 μM (CC50), Osteoblast:180 μg/mL, MCF-7 cells:41.6 μM, MG-63 cells:180 μg/mL, HeLa cells:> 400 μg/mL
In vitro	METHODS: Neuroblastoma cells were treated with Binimetinib (0-2 µM) for 24-120 h. Cell viability was measured by MTT assay. RESULTS: Four cell lines, CHP-212, SK-N-BE, SK-N-AS and SJ-NB-10, were sensitive to Binimetinib, achieving <50% survival after 24-120 h of treatment, while five cell lines were resistant to the drug. [1] METHODS: NSCLC cells A549, H157 and H522 were treated with Binimetinib (0.5-1 µM) for 48 h. Cell cycle was measured by flow cytometry. RESULTS: Binimetinib induced G1 phase block in three sensitive NSCLC cell lines at relatively low concentration ranges, e.g. 0.5 and 1 µM. [2]
In vivo	METHODS: To detect in vivo antitumor activity, Binimetinib (5 mg/kg) and BMK120 (7.5 mg/kg) were administered by gavage to athymic (nu/nu) mice bearing A549 xenografts once daily for 21 days. RESULTS: Binimetinib and BKM120 alone at the doses tested only weakly inhibited the growth of A549 xenografts, but the combination of Binimetinib and BKM120 significantly inhibited the growth of A549 xenografts. [2]
Synonyms	Tetracyclinum, Tetracyclin, Deschlorobiomycin

Chemical Properties

Molecular Weight	444.43
Formula	C₂₂H₂₄N₂O₈
Cas No.	60-54-8
Smiles	[H][C@@]12C[C@@]3([H])C(=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C)C(=O)c1c(O)cccc1[C@@]3(C)O
Relative Density.	1.644g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 262.5 mg/mL (590.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 15 mg/mL (33.75 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2501 mL	11.2504 mL	22.5007 mL	112.5037 mL
5 mM	0.4500 mL	2.2501 mL	4.5001 mL	22.5007 mL
10 mM	0.2250 mL	1.1250 mL	2.2501 mL	11.2504 mL
20 mM	0.1125 mL	0.5625 mL	1.1250 mL	5.6252 mL
50 mM	0.0450 mL	0.2250 mL	0.4500 mL	2.2501 mL
100 mM	0.0225 mL	0.1125 mL	0.2250 mL	1.1250 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc