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Anti-TNFR2/CD120b/TNFR1B Antibody (2S461)
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Catalog No. TMAY-00799
Alias tumor necrosis factor receptor superfamily, member 1b, TNF-R-II, TNFR80, TNF-R75, TNFR2, TNFR1B, TNFBR, TBPII, p75TNFR, p75, CD120b
Anti-TNFR2/CD120b/TNFR1B Antibody (2S461) is a Rabbit antibody targeting TNFR2/CD120b/TNFR1B. Anti-TNFR2/CD120b/TNFR1B Antibody (2S461) can be used in ELISA.
Anti-TNFR2/CD120b/TNFR1B Antibody (2S461)
Anti-TNFR2/CD120b/TNFR1B Antibody (2S461)
😃Good
Catalog No. TMAY-00799Alias tumor necrosis factor receptor superfamily, member 1b, TNF-R-II, TNFR80, TNF-R75, TNFR2, TNFR1B, TNFBR, TBPII, p75TNFR, p75, CD120b
Anti-TNFR2/CD120b/TNFR1B Antibody (2S461) is a Rabbit antibody targeting TNFR2/CD120b/TNFR1B. Anti-TNFR2/CD120b/TNFR1B Antibody (2S461) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $92 | 7-10 days | |
| 100 μL | $292 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA Reactivity: Human |
| Alias | tumor necrosis factor receptor superfamily, member 1b, TNF-R-II, TNFR80, TNF-R75, TNFR2, TNFR1B, TNFBR, TBPII, p75TNFR, p75, CD120b |
| Ig Type | Rabbit IgG |
| Clone | 2S461 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human TNFRSF1B / CD120b (rh TNFRSF1B; TMPY-01166; Met 1-Asp 257; NP_001057.1). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human TNFR2 protein (TMPY-01166) |
| Antigen Species | Human |
| Biology Area | Neuroinflammation |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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