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Anti-TNFR2/CD120b/TNFR1B Antibody (2S461)

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Catalog No. TMAY-00799
Alias tumor necrosis factor receptor superfamily, member 1b, TNF-R-II, TNFR80, TNF-R75, TNFR2, TNFR1B, TNFBR, TBPII, p75TNFR, p75, CD120b

Anti-TNFR2/CD120b/TNFR1B Antibody (2S461) is a Rabbit antibody targeting TNFR2/CD120b/TNFR1B. Anti-TNFR2/CD120b/TNFR1B Antibody (2S461) can be used in ELISA.

Anti-TNFR2/CD120b/TNFR1B Antibody (2S461)

Anti-TNFR2/CD120b/TNFR1B Antibody (2S461)

😃Good
Catalog No. TMAY-00799Alias tumor necrosis factor receptor superfamily, member 1b, TNF-R-II, TNFR80, TNF-R75, TNFR2, TNFR1B, TNFBR, TBPII, p75TNFR, p75, CD120b
Anti-TNFR2/CD120b/TNFR1B Antibody (2S461) is a Rabbit antibody targeting TNFR2/CD120b/TNFR1B. Anti-TNFR2/CD120b/TNFR1B Antibody (2S461) can be used in ELISA.
Pack SizePriceAvailabilityQuantity
20 μL$92 7-10 days
100 μL$292 7-10 days
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Product Introduction

Bioactivity
Description
Anti-TNFR2/CD120b/TNFR1B Antibody (2S461) is a Rabbit antibody targeting TNFR2/CD120b/TNFR1B. Anti-TNFR2/CD120b/TNFR1B Antibody (2S461) can be used in ELISA.
Aliastumor necrosis factor receptor superfamily, member 1b, TNF-R-II, TNFR80, TNF-R75, TNFR2, TNFR1B, TNFBR, TBPII, p75TNFR, p75, CD120b
Ig Type
Monoclonal Rabbit IgG
Clone
2S461
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human TNFRSF1B / CD120b (rh TNFRSF1B; TMPY-01166; Met 1-Asp 257; NP_001057.1).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundTumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human TNFR2 protein (TMPY-01166)
Antigen Species
Human
Biology Area
Neuroinflammation
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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