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BSc5367
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Catalog No. T60953Cas No. 3029584-84-4
BSc5367 is a potent inhibitor for the Nek1 kinase domain with an IC50 value of 11.5 nM. Nek1 is a NIMA-related protein kinase that crucially involved in cell cycle regulation, DNA repair and microtubule regulation. The Nek1 dysfunctions play key roles in amyotrophic lateral sclerosis (ALS), polycystic kidney disease (PKD) and several types of radiotherapy resistant cancer. BSc5367 provides a useful tool to better understand the aforementioned diseases[1].
BSc5367
BSc5367
😃Good
Catalog No. T60953Cas No. 3029584-84-4
BSc5367 is a potent inhibitor for the Nek1 kinase domain with an IC50 value of 11.5 nM. Nek1 is a NIMA-related protein kinase that crucially involved in cell cycle regulation, DNA repair and microtubule regulation. The Nek1 dysfunctions play key roles in amyotrophic lateral sclerosis (ALS), polycystic kidney disease (PKD) and several types of radiotherapy resistant cancer. BSc5367 provides a useful tool to better understand the aforementioned diseases[1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $676 | 10-14 weeks | |
| 50 mg | $879 | 10-14 weeks | |
| 100 mg | $1,360 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BSc5367 is a potent inhibitor for the Nek1 kinase domain with an IC50 value of 11.5 nM. Nek1 is a NIMA-related protein kinase that crucially involved in cell cycle regulation, DNA repair and microtubule regulation. The Nek1 dysfunctions play key roles in amyotrophic lateral sclerosis (ALS), polycystic kidney disease (PKD) and several types of radiotherapy resistant cancer. BSc5367 provides a useful tool to better understand the aforementioned diseases[1]. |
| Cas No. | 3029584-84-4 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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