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KRH102140

Name: KRH102140
Brand: TargetMol
SKU: T68511
Price: 330 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68511Cas No. 864769-01-7

Alias KRH 102140

KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.

KRH102140

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Purity: 99.61%

Catalog No. T68511Alias KRH 102140Cas No. 864769-01-7

KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.

Pack Size	Price	Availability
1 mg	$330	In Stock
5 mg	$790	In Stock
10 mg	$1,120	In Stock
25 mg	$1,670	In Stock
50 mg	$2,180	In Stock

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Purity:99.61%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.
Targets&IC50	5-LOX:160 nM
In vitro	KRH102140 is a PHD2 activator that effectively inhibits HIF-1α in hypoxic human osteosarcoma cells. In addition, KRH102140 reduced mRNA levels of downstream target genes of HIF regulation related to angiogenesis and energy metabolism. [1] KRH102140 inhibited 5-LO activity with an IC50 value of 160 ± 23 nmol/l and inhibited LTB in RBL-1 cells. [2]
In vivo	Oral administration of KRH102140 (10-100 mg/kg) reduced ear edema, myeloperoxidase activity, and LTB production in a mouse inflammatory model. The oral bioavailability of rats was 66%. [2]
Synonyms	KRH 102140

Chemical Properties

Molecular Weight	373.46
Formula	C₂₅H₂₄FNO
Cas No.	864769-01-7
Smiles	FC=1C=CC=CC1CNC=2C=CC=3OC(C=CC3C2)(C)CCC=4C=CC=CC4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (267.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6777 mL	13.3883 mL	26.7766 mL	133.8831 mL
5 mM	0.5355 mL	2.6777 mL	5.3553 mL	26.7766 mL
10 mM	0.2678 mL	1.3388 mL	2.6777 mL	13.3883 mL
20 mM	0.1339 mL	0.6694 mL	1.3388 mL	6.6942 mL
50 mM	0.0536 mL	0.2678 mL	0.5355 mL	2.6777 mL
100 mM	0.0268 mL	0.1339 mL	0.2678 mL	1.3388 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc