Shopping Cart

Your shopping cart is currently empty

KRH102140

Name: KRH102140
Brand: TargetMol
SKU: T68511
Price: 330 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T68511Cas No. 864769-01-7

Alias KRH 102140

KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.

KRH102140

😃Good

Purity: 99.61%

Catalog No. T68511Alias KRH 102140Cas No. 864769-01-7

KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$330	In Stock	In Stock
5 mg	$790	In Stock	In Stock
10 mg	$1,120	-	In Stock
25 mg	$1,670	-	In Stock
50 mg	$2,180	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.61%

Appearance:Viscous

Color:Transparent

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.
Targets&IC50	5-LOX:160 nM
In vitro	KRH102140 is a PHD2 activator that effectively inhibits HIF-1α in hypoxic human osteosarcoma cells. In addition, KRH102140 reduced mRNA levels of downstream target genes of HIF regulation related to angiogenesis and energy metabolism. [1] KRH102140 inhibited 5-LO activity with an IC50 value of 160 ± 23 nmol/l and inhibited LTB in RBL-1 cells. [2]
In vivo	Oral administration of KRH102140 (10-100 mg/kg) reduced ear edema, myeloperoxidase activity, and LTB production in a mouse inflammatory model. The oral bioavailability of rats was 66%. [2]
Synonyms	KRH 102140

Chemical Properties

Molecular Weight	373.46
Formula	C₂₅H₂₄FNO
Cas No.	864769-01-7
Smiles	FC=1C=CC=CC1CNC=2C=CC=3OC(C=CC3C2)(C)CCC=4C=CC=CC4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (267.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6777 mL	13.3883 mL	26.7766 mL	133.8831 mL
5 mM	0.5355 mL	2.6777 mL	5.3553 mL	26.7766 mL
10 mM	0.2678 mL	1.3388 mL	2.6777 mL	13.3883 mL
20 mM	0.1339 mL	0.6694 mL	1.3388 mL	6.6942 mL
50 mM	0.0536 mL	0.2678 mL	0.5355 mL	2.6777 mL
100 mM	0.0268 mL	0.1339 mL	0.2678 mL	1.3388 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc