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(+)-Afzelechin

Name: (+)-Afzelechin
Brand: TargetMol
SKU: TN1361
Rating: 4.5 (1 reviews)

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Catalog No. TN1361Cas No. 2545-00-8

Alias Afzelechin

(+)-Afzelechin (Afzelechin) is isolated from Eysenhardtia subcoriacea. It is an α-glucosidase activity inhibitor, offering neuroprotective effects against glutamate-induced neurotoxicity in HT22 cells and improving reduced glutathione levels in rat pancreas homogenates.

(+)-Afzelechin

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Catalog No. TN1361Alias AfzelechinCas No. 2545-00-8

Pack Size	Price	Availability	Quantity
1 mg	$458	Backorder
5 mg	$1,018	Backorder

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Product Introduction

Bioactivity

Description	(+)-Afzelechin (Afzelechin) is isolated from Eysenhardtia subcoriacea. It is an α-glucosidase activity inhibitor, offering neuroprotective effects against glutamate-induced neurotoxicity in HT22 cells and improving reduced glutathione levels in rat pancreas homogenates.
Targets&IC50	α-glucosidase:0.13 mM(ID50)
In vitro	Treatment of human umbilical vein endothelial cells (HUVECs) with (+)-Afzelechin (20 μM, 6h) effectively inhibited the production of iNOS and prevented LPS-induced NO synthesis. (+)-AfzelechinC (2-20 μM, 6h) demonstrated its anti-inflammatory ability by down-regulating IL-1β expression in LPS-treated HUVEC. [1] (+)-Afzelechin improves the efficacy of sepsis induced ALI by modulating TLR4/NF-κB, PI3K/Akt, Hippo, and Rho signaling pathways to reduce inflammation. [2]
In vivo	(+)-Afzelechin (0.04-0.4 mg/kg, intravenously), results showed significantly reduced iNOS expression in mice with LPS-induced lung injury models, indicating the anti-inflammatory activity of (+)-Afzelechin in vivo. [1]
Synonyms	Afzelechin

Chemical Properties

Molecular Weight	274.27
Formula	C₁₅H₁₄O₅
Cas No.	2545-00-8
Smiles	OC1=C2C(O[C@@H]([C@@H](O)C2)C3=CC=C(O)C=C3)=CC(O)=C1
Relative Density.	1.492 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (291.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6460 mL	18.2302 mL	36.4604 mL	182.3021 mL
5 mM	0.7292 mL	3.6460 mL	7.2921 mL	36.4604 mL
10 mM	0.3646 mL	1.8230 mL	3.6460 mL	18.2302 mL
20 mM	0.1823 mL	0.9115 mL	1.8230 mL	9.1151 mL
50 mM	0.0729 mL	0.3646 mL	0.7292 mL	3.6460 mL
100 mM	0.0365 mL	0.1823 mL	0.3646 mL	1.8230 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc