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SDZ 220-581 hydrochloride

Name: SDZ 220-581 hydrochloride
Brand: TargetMol
SKU: T12889L
Rating: 4.5 (1 reviews)

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Catalog No. T12889LCas No. 179411-93-9

SDZ 220-581 hydrochloride is a potent, orally active and competitive antagonist of NMDA receptor(pKi : 7.7).

SDZ 220-581 hydrochloride

😃Good

Catalog No. T12889LCas No. 179411-93-9

SDZ 220-581 hydrochloride is a potent, orally active and competitive antagonist of NMDA receptor(pKi : 7.7).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$73	5 days	5 days
1 mL x 10 mM (in DMSO)	$186	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	SDZ 220-581 hydrochloride is a potent, orally active and competitive antagonist of NMDA receptor(pKi : 7.7).
Targets&IC50	NMDAR:pki： 7.7

Chemical Properties

Molecular Weight	406.2
Formula	C₁₆H₁₈Cl₂NO₅P
Cas No.	179411-93-9
Smiles	ClC1=C(C2=CC(C[C@@H](C(O)=O)N)=CC(CP(=O)(O)O)=C2)C=CC=C1.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5 mg/mL (12.31 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4618 mL	12.3092 mL	24.6184 mL	123.0921 mL
5 mM	0.4924 mL	2.4618 mL	4.9237 mL	24.6184 mL
10 mM	0.2462 mL	1.2309 mL	2.4618 mL	12.3092 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc