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SDZ 220-581 hydrochloride

Name: SDZ 220-581 hydrochloride
Brand: TargetMol
SKU: T12889L
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T12889L Copy Product Info

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SDZ 220-581 hydrochloride is a highly potent competitive NMDA receptor antagonist with good oral bioavailability and a pKᵢ of 7.7.

SDZ 220-581 hydrochloride

Copy Product Info

🥰Excellent

Catalog No. T12889L

SDZ 220-581 hydrochloride is a highly potent competitive NMDA receptor antagonist with good oral bioavailability and a pKᵢ of 7.7.

Cas No. 179411-93-9

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$58	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	SDZ 220-581 hydrochloride is a highly potent competitive NMDA receptor antagonist with good oral bioavailability and a pKᵢ of 7.7.
Targets&IC50	NMDAR:pki： 7.7 , NMDA:7.7 (pKi)
In vivo	Methods: Male OF-l mice were selected and orally administered with SDZ 220-581 hydrochloride at doses of 3.2–32 mg/kg for 24 hours to observe its protective effect and time-effect characteristics on maximal electroshock seizures (MES). Results: SDZ 220-581 hydrochloride could protect mice against maximal electroshock seizures in a dose-dependent manner, with a rapid onset and long duration of protective effect [1].

Chemical Properties

Molecular Weight	406.20
Formula	C₁₆H₁₈Cl₂NO₅P
Cas No.	179411-93-9
Smiles	ClC1=C(C2=CC(C[C@@H](C(O)=O)N)=CC(CP(=O)(O)O)=C2)C=CC=C1.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4.00 mg/mL (9.85 mM), Sonication and heating are recommended

H2O: < 1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4618 mL	12.3092 mL	24.6184 mL	123.0921 mL
5 mM	0.4924 mL	2.4618 mL	4.9237 mL	24.6184 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc