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RO7185876

🥰Excellent
TargetMol
Catalog No. T39702Cas No. 2226038-71-5

RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.

RO7185876

RO7185876

🥰Excellent
TargetMol
Purity: 99.50%
Catalog No. T39702Cas No. 2226038-71-5
RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.
Pack SizePriceAvailabilityQuantity
1 mg$293In Stock
5 mg$722In Stock
10 mg$987In Stock
25 mg$1,520In Stock
50 mg$1,980In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.50%
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Product Introduction

Bioactivity
Description
RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.
Chemical Properties
Molecular Weight483.532
FormulaC25H28F3N7
Cas No.2226038-71-5
SmilesN(C=1N=C2[C@@H](CCCCN2N1)C3=C(F)C(F)=C(F)C=C3)[C@H]4[C@@]5(CN(C[C@]4(CC5)[H])C=6C=C(C)N=CN6)[H]
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 25 mg/mL (51.7 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0681 mL10.3406 mL20.6812 mL103.4058 mL
5 mM0.4136 mL2.0681 mL4.1362 mL20.6812 mL
10 mM0.2068 mL1.0341 mL2.0681 mL10.3406 mL
20 mM0.1034 mL0.5170 mL1.0341 mL5.1703 mL
50 mM0.0414 mL0.2068 mL0.4136 mL2.0681 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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