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Imrecoxib

Name: Imrecoxib
Brand: TargetMol
SKU: T15571
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15571Cas No. 395683-14-4

Alias BAP-909

Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor (IC50: 18 nM) that also inhibits COX-1 activity (IC50: 115 nM) and exhibits anti-inflammatory effects.

Imrecoxib

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Purity: 99.87%

Catalog No. T15571Alias BAP-909Cas No. 395683-14-4

Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor (IC50: 18 nM) that also inhibits COX-1 activity (IC50: 115 nM) and exhibits anti-inflammatory effects.

Pack Size	Price	Availability	Quantity
25 mg	$30	In Stock
1 mL x 10 mM (in DMSO)	$36	In Stock

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Purity:99.87%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor (IC50: 18 nM) that also inhibits COX-1 activity (IC50: 115 nM) and exhibits anti-inflammatory effects.
Targets&IC50	COX-2:115 nM, COX-2(human):18 nM, COX-1:115 nM
In vitro	In U937 cells, Imrecoxib (0.1-10 μM; 24 hours) reduces COX-2 mRNA level induced by PMA+LPS in a dose-dependent manner.
In vivo	Imrecoxib (gastrointestinal administration; 5-20 mg/kg; started on day 7; 26 days) diminishes the secondary paw swelling. It also inhibits heat-inactivated BCG induced-inflammtory polyarthritis. Imrecoxib (gastrointestinal administration; 5-20 mg/kg; 1 hour before carrageenan injection) suppresses carrageenan-induced acute inflammation, and the inhibitory effect is maximal at 4 hours.
Synonyms	BAP-909

Chemical Properties

Molecular Weight	369.48
Formula	C₂₁H₂₃NO₃S
Cas No.	395683-14-4
Smiles	CCCN1CC(=C(C1=O)c1ccc(C)cc1)c1ccc(cc1)S(C)(=O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (243.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7065 mL	13.5325 mL	27.0651 mL	135.3253 mL
5 mM	0.5413 mL	2.7065 mL	5.4130 mL	27.0651 mL
10 mM	0.2707 mL	1.3533 mL	2.7065 mL	13.5325 mL
20 mM	0.1353 mL	0.6766 mL	1.3533 mL	6.7663 mL
50 mM	0.0541 mL	0.2707 mL	0.5413 mL	2.7065 mL
100 mM	0.0271 mL	0.1353 mL	0.2707 mL	1.3533 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc