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Diphenyleneiodonium chloride

Diphenyleneiodonium chloride
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity.
Catalog No. T7191Cas No. 4673-26-1
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Diphenyleneiodonium chloride

Catalog No. T7191Cas No. 4673-26-1

Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity.
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Pack SizePriceAvailabilityQuantity
5 mg$38In Stock
10 mg$61In Stock
25 mg$109In Stock
50 mg$198In Stock
100 mg$343In Stock
1 mL x 10 mM (in DMSO)$66In Stock
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Product Introduction

Bioactivity
Description
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity.
Targets&IC50
iNOS:50 nM , eNOS:0.3 µM
In vitro
Diphenyleneiodonium chloride (DPIC), an NADPH/NADH oxidase inhibitor, as possessing potent antimicrobial activity against non-tuberculous mycobacteria.?DPIC exhibited concentration-dependent bactericidal activity against M. fortuitum and synergized with amikacin, ceftriaxone, ceftazidime and meropenem[1].
Cell Research
Whole-cell growth inhibition assays were used to screen and identify novel inhibitors. The hit compounds(Diphenyleneiodonium chloride) were tested for cytotoxicity against Vero cells to determine the selectivity index, and time-kill kinetics were determined against Mycobacterium fortuitum. The compound's ability to synergize with amikacin, ceftriaxone, ceftazidime and meropenem was determined using fractional inhibitory concentration indexes followed by its ability to decimate mycobacterial infections ex vivo[1].
AliasDPI
Chemical Properties
Molecular Weight314.55
FormulaC12H8ClI
Cas No.4673-26-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 6 mg/mL (19.07 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1791 mL15.8957 mL31.7914 mL158.9572 mL
5 mM0.6358 mL3.1791 mL6.3583 mL31.7914 mL
10 mM0.3179 mL1.5896 mL3.1791 mL15.8957 mL

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