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Anti-TLT-1/TREML1 Antibody (1H513)

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Catalog No. TMAY-02155

Anti-TLT-1/TREML1 Antibody (1H513) is a Rabbit antibody targeting TLT-1/TREML1. Anti-TLT-1/TREML1 Antibody (1H513) can be used in ELISA(Det).

Anti-TLT-1/TREML1 Antibody (1H513)

Anti-TLT-1/TREML1 Antibody (1H513)

🥰Excellent
Catalog No. TMAY-02155
Anti-TLT-1/TREML1 Antibody (1H513) is a Rabbit antibody targeting TLT-1/TREML1. Anti-TLT-1/TREML1 Antibody (1H513) can be used in ELISA(Det).
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Product Introduction

Bioactivity
Description
Anti-TLT-1/TREML1 Antibody (1H513) is a Rabbit antibody targeting TLT-1/TREML1. Anti-TLT-1/TREML1 Antibody (1H513) can be used in ELISA(Det).
Ig Type
Monoclonal Rabbit IgG
Clone
1H513
Reactivity
Human
Application
ELISA(Det)
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human TLT-1 / TREML1 (rh TLT-1 / TREML1; TMPY-01840; Q86YW5-1; Met1-Pro162).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundTrem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that its expression is up-regulated dramatically upon platelet activation. It is a receptor that may play a role in the innate and adaptive immune response. TREML1 / TLT-1 contains the characteristic single V-set immunoglobulin (Ig) domain, its longer cytoplasmic tail is composed of both a proline-rich region and an immune receptor tyrosine-based inhibitory motif, the latter known to be used for interactions with protein tyrosine phosphatases. The triggering receptors expressed on myeloid cells (TREMs) have drawn considerable attention due to their ability to activate multiple cell types within the innate immune system, including neutrophils, monocyte / macrophages, and dendritic cells, via their association with DAP12. TREML1 / TLT-1 is prepackaged, along with CD62P, into both MK and platelet alpha-granules. Differences in thrombin-induced redistribution of CD62P and TREML1 indicate that TREML1 is not simply cargo of alpha-granules but may instead regulate granule construction or dispersal. TREML1 / TLT-1 does not function to inhibit members of the TREM family but instead may play a role in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
HRP
Antibody Types Available
2
Antigen Details
Immunogen
Recombinant Human TLT-1 / TREML1 Protein (TMPY-01840)
Antigen Species
Human
Biology Area
ITIM/ITAM Immunoreceptors and Related Molecules
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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