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A-802715

Name: A-802715
Brand: TargetMol
SKU: T14075
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14075Cas No. 107767-58-8

A-802715 is a novel methylxanthine derivative that decreases the endogenous formation and blood levels of pro-inflammatory substances and increases the formation and blood levels of anti-inflammatory substances such as interleukin 10 receptor and tumor necrosis factor receptor.

A-802715

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Purity: 96.29%

Catalog No. T14075Cas No. 107767-58-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	-	In Stock
5 mg	$218	-	In Stock
1 mL x 10 mM (in DMSO)	$238	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:96.29%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

In vitro

The toxicity of the methylxanthine derivative A802715 was evaluated using vital dye staining assays against two human melanoma lines, Be11 and MeWo, and two human squamous cell carcinoma lines, 4197 and 4451. A802715 demonstrated the highest toxicity, with a TD50 of 0.9-1.1 mM. BrdU incorporation assays in p53 wt cells indicated that A802715 significantly enhances irradiation-induced suppression of S-phase entry. Depending on the p53 status, A802715 either prolongs the G2/M block or remains ineffective [1].

Chemical Properties

Molecular Weight	322.4
Formula	C₁₆H₂₆N₄O₃
Cas No.	107767-58-8
Smiles	CCCn1cnc2n(C)c(=O)n(CCCCC(C)(C)O)c(=O)c12
Relative Density.	1.22 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (186.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (15.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1017 mL	15.5087 mL	31.0174 mL	155.0868 mL
5 mM	0.6203 mL	3.1017 mL	6.2035 mL	31.0174 mL
10 mM	0.3102 mL	1.5509 mL	3.1017 mL	15.5087 mL
20 mM	0.1551 mL	0.7754 mL	1.5509 mL	7.7543 mL
50 mM	0.0620 mL	0.3102 mL	0.6203 mL	3.1017 mL
100 mM	0.0310 mL	0.1551 mL	0.3102 mL	1.5509 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc