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Loxapine succinate

Name: Loxapine succinate
Brand: TargetMol
SKU: T1412
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1412Cas No. 27833-64-3

Alias Loxapine succinate salt, Loxapac, Daxolin, Cloxazepin

Loxapine succinate (Loxapac), a D2DR and D4DR inhibitor, is utilized in schizophrenia.

Loxapine succinate

😃Good

Purity: 99.69%

Catalog No. T1412Alias Loxapine succinate salt, Loxapac, Daxolin, CloxazepinCas No. 27833-64-3

Loxapine succinate (Loxapac), a D2DR and D4DR inhibitor, is utilized in schizophrenia.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$33	In Stock	In Stock
100 mg	$47	In Stock	In Stock
200 mg	$76	In Stock	In Stock
500 mg	$167	Backorder	Backorder
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.69%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Loxapine succinate (Loxapac), a D2DR and D4DR inhibitor, is utilized in schizophrenia.
Targets&IC50	5-HT2 (bovine):6.6 nM(Ki), 5-HT2 (bovine):6.8 nM(Ki), 5-HT2 (human):6.2 nM(Ki), D4 receptor (human):7.5 nM(Ki), D2 receptor (human):24 nM(Ki)
In vitro	In rats, subcutaneous injection of Loxapine (0.3 mg/kg) induces general stiffness. In the rat brain, administering Loxapine (5 mg/kg) does not alter dopamine receptor density, but it reduces serotonin receptor density.
In vivo	Loxapine effectively facilitates the binding of [3H]ketanserin to 5-HT2 receptors in both the human frontal cortex (ki=6.2 nM) and the bovine frontal cortex (ki=6.6 nM). Additionally, in LPS-activated mixed glial cells, loxapine at concentrations of 0.2 μM, 2 μM, and 20 μM, successfully reduces the secretion of IL-1β and IL-2.
Synonyms	Loxapine succinate salt, Loxapac, Daxolin, Cloxazepin

Chemical Properties

Molecular Weight	445.9
Formula	C₂₂H₂₄ClN₃O₅
Cas No.	27833-64-3
Smiles	OC(=O)CCC(=O)O.CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 2 mg/mL (4.49 mM), Sonication is recommended.

DMSO: 82 mg/mL (183.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2427 mL	11.2133 mL	22.4266 mL	112.1328 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.4485 mL	2.2427 mL	4.4853 mL	22.4266 mL
10 mM	0.2243 mL	1.1213 mL	2.2427 mL	11.2133 mL
20 mM	0.1121 mL	0.5607 mL	1.1213 mL	5.6066 mL
50 mM	0.0449 mL	0.2243 mL	0.4485 mL	2.2427 mL
100 mM	0.0224 mL	0.1121 mL	0.2243 mL	1.1213 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc