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Loxapine succinate

Name: Loxapine succinate
Brand: TargetMol
SKU: T1412
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1412Cas No. 27833-64-3

Alias Loxapine succinate salt, Loxapac, Daxolin, Cloxazepin

Loxapine succinate (Loxapac), a D2DR and D4DR inhibitor, is utilized in schizophrenia.

Loxapine succinate

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Purity: 99.69%

Catalog No. T1412Alias Loxapine succinate salt, Loxapac, Daxolin, CloxazepinCas No. 27833-64-3

Loxapine succinate (Loxapac), a D2DR and D4DR inhibitor, is utilized in schizophrenia.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$33	In Stock	In Stock
100 mg	$47	In Stock	In Stock
200 mg	$76	In Stock	In Stock
500 mg	$167	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.69%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Loxapine succinate (Loxapac), a D2DR and D4DR inhibitor, is utilized in schizophrenia.
Targets&IC50	5-HT2 (bovine):6.6 nM(Ki), 5-HT2 (bovine):6.8 nM(Ki), D4 receptor (human):7.5 nM(Ki), 5-HT2 (human):6.2 nM(Ki), D2 receptor (human):24 nM(Ki)
In vitro	In rats, subcutaneous injection of Loxapine (0.3 mg/kg) induces general stiffness. In the rat brain, administering Loxapine (5 mg/kg) does not alter dopamine receptor density, but it reduces serotonin receptor density.
In vivo	Loxapine effectively facilitates the binding of [3H]ketanserin to 5-HT2 receptors in both the human frontal cortex (ki=6.2 nM) and the bovine frontal cortex (ki=6.6 nM). Additionally, in LPS-activated mixed glial cells, loxapine at concentrations of 0.2 μM, 2 μM, and 20 μM, successfully reduces the secretion of IL-1β and IL-2.
Synonyms	Loxapine succinate salt, Loxapac, Daxolin, Cloxazepin

Chemical Properties

Molecular Weight	445.9
Formula	C₂₂H₂₄ClN₃O₅
Cas No.	27833-64-3
Smiles	OC(=O)CCC(=O)O.CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 2 mg/mL (4.49 mM), Sonication is recommended.

DMSO: 82 mg/mL (183.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2427 mL	11.2133 mL	22.4266 mL	112.1328 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.4485 mL	2.2427 mL	4.4853 mL	22.4266 mL
10 mM	0.2243 mL	1.1213 mL	2.2427 mL	11.2133 mL
20 mM	0.1121 mL	0.5607 mL	1.1213 mL	5.6066 mL
50 mM	0.0449 mL	0.2243 mL	0.4485 mL	2.2427 mL
100 mM	0.0224 mL	0.1121 mL	0.2243 mL	1.1213 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc