Shopping Cart
Remove All
Your shopping cart is currently empty
Perifosine
🥰Excellent
Catalog No. T2492Cas No. 157716-52-4
Alias NSC 639966, KRX-0401, D21266
Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity.
Perifosine
🥰Excellent
Purity: 99.94%
Catalog No. T2492Alias NSC 639966, KRX-0401, D21266Cas No. 157716-52-4
Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $39 | In Stock | In Stock | |
| 5 mg | $63 | In Stock | In Stock | |
| 10 mg | $81 | In Stock | In Stock | |
| 25 mg | $163 | In Stock | In Stock | |
| 50 mg | $297 | In Stock | In Stock | |
| 100 mg | $468 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.94%
Color:White
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity. |
| Targets&IC50 | Akt:4.7 μM |
| In vitro | In MM.1S cells, Perifosine (10 μM) completely inhibited Akt phosphorylation. In immortalized keratinocytes and head and neck squamous carcinoma cells (IC50=0.6-8.9 μM), Perifosine inhibited cell proliferation. In mouse glial progenitor cells, Perifosine induced cell cycle arrest at G1 and G2 by reducing the phosphorylation level of Akt and extracellular signal-regulated kinases, causing cell growth inhibition. In human hepatocellular carcinoma cells, Perifosine induced cell cycle arrest and apoptosis by blocking Akt phosphorylation. |
| In vivo | In MM.1S cells, Perifosine (10 μM) completely inhibited Akt phosphorylation. In immortalized keratinocytes and head and neck squamous carcinoma cells (IC50=0.6-8.9 μM), Perifosine inhibited cell proliferation. In mouse glial progenitor cells, Perifosine induced cell cycle arrest at G1 and G2 by reducing the phosphorylation level of Akt and extracellular signal-regulated kinases, causing cell growth inhibition. In human hepatocellular carcinoma cells, Perifosine induced cell cycle arrest and apoptosis by blocking Akt phosphorylation. |
| Kinase Assay | Akt kinase assay: MM.1S cells are cultured in the presence or absence of perifosine (5 μM, 6 hours) and then stimulated with IL-6 (20 ng/mL, 10 minutes). In vitro akt kinase assay is then carried out using the Akt Kinase Assay Kit. |
| Cell Research | Cells are incubated in the medium with 10% FCS for 48 hours with indicated concentration of Periosine. Cell viability is determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. (Cell Proliferation Kit I; Roche). The absorbance at 590 nm is recorded using the 96-well plate reader.(Only for Reference) |
| Synonyms | NSC 639966, KRX-0401, D21266 |
| Molecular Weight | 461.66 |
| Formula | C25H52NO4P |
| Cas No. | 157716-52-4 |
| Smiles | O(P(OCCCCCCCCCCCCCCCCCC)(=O)[O-])C1CC[N+](C)(C)CC1 |
| Relative Density. | no data available |
| Storage | keep away from moisture,store at low temperature,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: Insoluble H2O: 10 mM, Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Perifosine | purchase Perifosine | Perifosine cost | order Perifosine | Perifosine chemical structure | Perifosine in vivo | Perifosine in vitro | Perifosine formula | Perifosine molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.