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BMS-214662

Name: BMS-214662
Brand: TargetMol
SKU: T10567
Rating: 4.5 (1 reviews)

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Catalog No. T10567Cas No. 195987-41-8

Alias BMS214662

BMS-214662 is a selective farnesyl transferase inhibitor with antitumor activity, useful in studies of pancreatic, head and neck, and lung cancers.

BMS-214662

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Purity: 99.58%

Catalog No. T10567Alias BMS214662Cas No. 195987-41-8

BMS-214662 is a selective farnesyl transferase inhibitor with antitumor activity, useful in studies of pancreatic, head and neck, and lung cancers.

Pack Size	Price	Availability
25 mg	$2,270	10-14 weeks
50 mg	$2,980	10-14 weeks
100 mg	$4,000	10-14 weeks

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.58%

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Product Introduction

Bioactivity

Description	BMS-214662 is a selective farnesyl transferase inhibitor with antitumor activity, useful in studies of pancreatic, head and neck, and lung cancers.
Targets&IC50	KRas:8.4 nM, H-Ras:1.3 nM
In vitro	BMS-214662 is a potent selective farnesyl transferase (FTI) inhibitor with antitumor activity. [2] BMS-214662 (250 nM, 24h) induces mitochondrial apoptosis in chronic myelogenous leukemia (CmL) stem/progenitor cells, including CD34+38- cells, by activating protein kinase Cbeta. [1]
In vivo	HCT-116 xenograft mice, BMS-214662 (250 mg/kg intravenously,300 mg/kg or 400 mg/kg orally), induced tumor cell apoptosis. For HCT-116 and EJ-1 tumors, the doses of BMS-214662 required to kill 90% of cloned tumor-forming cells were approximately 75 and 100 mg/kg, respectively. [3]
Synonyms	BMS214662

Chemical Properties

Molecular Weight	489.61
Formula	C₂₅H₂₃N₅O₂S₂
Cas No.	195987-41-8
Smiles	C([C@H]1N(S(=O)(=O)C2=CC=CS2)CC=3C(N(CC4=CN=CN4)C1)=CC=C(C#N)C3)C5=CC=CC=C5
Relative Density.	1.45 g/cm3 (Predicted)
Color	Yellow
Appearance	Viscous

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 80 mg/mL (163.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0424 mL	10.2122 mL	20.4244 mL	102.1221 mL
5 mM	0.4085 mL	2.0424 mL	4.0849 mL	20.4244 mL
10 mM	0.2042 mL	1.0212 mL	2.0424 mL	10.2122 mL
20 mM	0.1021 mL	0.5106 mL	1.0212 mL	5.1061 mL
50 mM	0.0408 mL	0.2042 mL	0.4085 mL	2.0424 mL
100 mM	0.0204 mL	0.1021 mL	0.2042 mL	1.0212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc