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Yakuchinone B

🥰Excellent
Catalog No. TN8931Cas No. 81840-57-5
Alias (1E)-1-(4-Hydroxy-3-methoxyphenyl)-7-phenyl-1-hepten-3-one

Yakuchinone B is an acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor with cholesterol-lowering activity, identified in the seeds of the Zingiberaceae family. It inhibits rat liver ACAT with an IC50 value of 20.6 μM. Yakuchinone B is a potential candidate for research into hypercholesterolemia and atherosclerosis.

Yakuchinone B

Yakuchinone B

🥰Excellent
Purity: 99.19%
Catalog No. TN8931Alias (1E)-1-(4-Hydroxy-3-methoxyphenyl)-7-phenyl-1-hepten-3-oneCas No. 81840-57-5
Yakuchinone B is an acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor with cholesterol-lowering activity, identified in the seeds of the Zingiberaceae family. It inhibits rat liver ACAT with an IC50 value of 20.6 μM. Yakuchinone B is a potential candidate for research into hypercholesterolemia and atherosclerosis.
Pack SizePriceAvailabilityQuantity
1 mg$61In Stock
5 mg$147In Stock
10 mg$236In Stock
25 mg$475In Stock
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Purity:99.19%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Yakuchinone B is an acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor with cholesterol-lowering activity, identified in the seeds of the Zingiberaceae family. It inhibits rat liver ACAT with an IC50 value of 20.6 μM. Yakuchinone B is a potential candidate for research into hypercholesterolemia and atherosclerosis.
Synonyms(1E)-1-(4-Hydroxy-3-methoxyphenyl)-7-phenyl-1-hepten-3-one
Chemical Properties
Molecular Weight310.39
FormulaC20H22O3
Cas No.81840-57-5
SmilesC(=C/C(CCCCC1=CC=CC=C1)=O)\C2=CC(OC)=C(O)C=C2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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