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ZSET-845

Name: ZSET-845
Brand: TargetMol
SKU: T13975
Rating: 4.5 (1 reviews)

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Catalog No. T13975Cas No. 324077-62-5

ZSET-845 is an enhancer of cognitive which enhances choline acetyltransferase activity in the hippocampus in the rat.

ZSET-845

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Catalog No. T13975Cas No. 324077-62-5

ZSET-845 is an enhancer of cognitive which enhances choline acetyltransferase activity in the hippocampus in the rat.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	ZSET-845 is an enhancer of cognitive which enhances choline acetyltransferase activity in the hippocampus in the rat.
In vitro	In NB-1 cells, ZSET-845 has no inhibitory action on AChE activity and enhances choline acetyltransferase (ChAT) activity[1].
In vivo	Administered orally, ZSET-845 at doses of 0.01, 0.1, and 1 mg/kg significantly improves scopolamine-induced performance impairments. In the hippocampus, ZSET-845 enhances ChAT (choline acetyltransferase) activity, with increases noted at 112%, 113.8%, and 108.7% for the respective doses, when compared to control rats receiving a matched vehicle [1]. Moreover, ZSET-845 at concentrations of 1 or 10 mg/kg not only mitigates learning deficits in a passive avoidance task but also elevates ChAT activity within the basal forebrain, medial septum, and hippocampus. Additionally, it boosts the count of ChAT-immunoreactive cells in the medial septum among Ab-treated rats back to levels observed in vehicle-injected control rats [2].

Chemical Properties

Molecular Weight	314.38
Formula	C₂₁H₁₈N₂O
Cas No.	324077-62-5
Smiles	C(C1(CC2=CC=CC=C2)N3C(=NC1=O)C=CC=C3)C4=CC=CC=C4
Relative Density.	1.14 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc