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CP-10

Name: CP-10
Brand: TargetMol
SKU: T13627
Rating: 4.5 (1 reviews)

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Catalog No. T13627Cas No. 2366268-80-4

CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6.

CP-10

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Catalog No. T13627Cas No. 2366268-80-4

Pack Size	Price	Availability
5 mg	$728	Backorder
10 mg	$996	Backorder
50 mg	$2,190	Backorder
100 mg	Inquiry	Backorder
200 mg	Inquiry	Backorder
1 mL x 10 mM (in DMSO)	$1,057	Backorder

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Product Introduction

Bioactivity

Description	CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6.
Targets&IC50	Cereblon:, CDK6:2.1 nM (Dc50)
In vitro	In human glioblastoma U251 cells, CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC50: 50-80 fold). CP-10 displays a cell inhibition potential in mantle cell lymphoma cells (in Mino, IC50≈8 nM) and multiple myeloma cell MM.1S (IC50≈10 nM).

Chemical Properties

Molecular Weight	871.94
Formula	C₄₄H₄₉N₁₃O₇
Cas No.	2366268-80-4
Relative Density.	1.55 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (229.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1469 mL	5.7343 mL	11.4687 mL	57.3434 mL
5 mM	0.2294 mL	1.1469 mL	2.2937 mL	11.4687 mL
10 mM	0.1147 mL	0.5734 mL	1.1469 mL	5.7343 mL
20 mM	0.0573 mL	0.2867 mL	0.5734 mL	2.8672 mL
50 mM	0.0229 mL	0.1147 mL	0.2294 mL	1.1469 mL
100 mM	0.0115 mL	0.0573 mL	0.1147 mL	0.5734 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc