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CP-10

CP-10
CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6.
Catalog No. T13627Cas No. 2366268-80-4

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CP-10

Catalog No. T13627Cas No. 2366268-80-4

CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6.
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Pack SizePriceAvailabilityQuantity
5 mg$728Backorder
10 mg$996Backorder
50 mg$2,190Backorder
100 mgInquiryBackorder
200 mgInquiryBackorder
1 mL x 10 mM (in DMSO)$1,057Backorder
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Product Introduction

Bioactivity
Description
CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6.
Targets&IC50
Cereblon:, CDK6:2.1 nM (Dc50)
In vitro
In human glioblastoma U251 cells, CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC50: 50-80 fold). CP-10 displays a cell inhibition potential in mantle cell lymphoma cells (in Mino, IC50≈8 nM) and multiple myeloma cell MM.1S (IC50≈10 nM).
Chemical Properties
Molecular Weight871.94
FormulaC44H49N13O7
Cas No.2366268-80-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 200 mg/mL (229.37 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1469 mL5.7343 mL11.4687 mL57.3434 mL
5 mM0.2294 mL1.1469 mL2.2937 mL11.4687 mL
10 mM0.1147 mL0.5734 mL1.1469 mL5.7343 mL
20 mM0.0573 mL0.2867 mL0.5734 mL2.8672 mL
50 mM0.0229 mL0.1147 mL0.2294 mL1.1469 mL
100 mM0.0115 mL0.0573 mL0.1147 mL0.5734 mL

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