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Lawsone

Name: Lawsone
Brand: TargetMol
SKU: T2969
Rating: 4.5 (1 reviews)

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Catalog No. T2969Cas No. 83-72-7

Alias Hennotannic acid, 2-hydroxy-1,4-naphthoquinone

Lawsone (Hennotannic acid) (2-hydroxy-1,4-naphthoquinone), also known as hennotannic acid, is a red-orange dye present in the leaves of the henna plant (Lawsonia inermis) as well as in the flower of water hyacinth (Eichhornia crassipes).

Lawsone

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Purity: 99.58%

Catalog No. T2969Alias Hennotannic acid, 2-hydroxy-1,4-naphthoquinoneCas No. 83-72-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 g	$31	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.58%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Lawsone AI Summary

Lawsone demonstrates a broad spectrum of bioactivities across various assays and targets. Notably, it shows significant bioactivity in eliminating the infective trypomastigote form of Trypanosoma cruzi in infected mice with a lysis rate of 76.0% at 0.29 mM. In terms of antimicrobial properties, it exhibits potent activity against Porphyromonas gingivalis and Streptococcus mutans, with complete inhibition at 7.8 ug/ml and inhibition of biofilm formation at 31.3 ug/ml, respectively. The compound also shows moderate growth inhibition on human Hs683 and A549 cells with IC50 values of 31,000 nM and 58,000 nM, respectively, while exhibiting negligible growth inhibition on other cancer cell lines. Moreover, Lawsone displays antimalarial properties with an IC50 of 100,000 nM against P. falciparum (Vietnam Smith strain) and demonstrates inhibitory activity against multiple human proteins such as MMPs, showing an inhibition rate of 84-86% at 1 mM concentration after 30 minutes. Its efficacy extends to inflammatory responses, evidenced by inhibition of croton oil-induced ear edema in CD1 mice at 0.3 umol/cm². In addition, the compound exhibits neuroprotective properties in mouse HT22 cells with a PD50 of 1005.0 nM, indicating prevention of glutamate-induced oxidative cell death. However, it has a low inhibitory activity against targets such as human rhinovirus 3C protease, HIV-1 integrase, and HIV-1 protease with IC50 values greater than 100,000 nM. Finally, the compound also shows enzymatic inhibition, with a notable inhibition (82%) of papain at 1.3 mM and inhibitory activities against cruzain and rhodesain enzymes of Trypanosoma species. Despite its cytotoxicity against various cell lines, its therapeutic index of 100.0 supports a favorable balance between efficacy and safety. Lawsone is soluble in water (255.0 ug.mL^-1) and has a logP value of 1.07, contributing to its varied biological effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Lawsone (Hennotannic acid) (2-hydroxy-1,4-naphthoquinone), also known as hennotannic acid, is a red-orange dye present in the leaves of the henna plant (Lawsonia inermis) as well as in the flower of water hyacinth (Eichhornia crassipes).
Synonyms	Hennotannic acid, 2-hydroxy-1,4-naphthoquinone

Chemical Properties

Molecular Weight	174.15
Formula	C₁₀H₆O₃
Cas No.	83-72-7
Smiles	O=C1C=2C(C(=O)C=C1O)=CC=CC2
Relative Density.	1.46 g/cm3 (25°C)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1435.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.7422 mL	28.7109 mL	57.4218 mL	287.1088 mL
5 mM	1.1484 mL	5.7422 mL	11.4844 mL	57.4218 mL
10 mM	0.5742 mL	2.8711 mL	5.7422 mL	28.7109 mL
20 mM	0.2871 mL	1.4355 mL	2.8711 mL	14.3554 mL
50 mM	0.1148 mL	0.5742 mL	1.1484 mL	5.7422 mL
100 mM	0.0574 mL	0.2871 mL	0.5742 mL	2.8711 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc