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P11149

Name: P11149
Brand: TargetMol
SKU: T38005
Rating: 4.5 (1 reviews)

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Catalog No. T38005Cas No. 164724-79-2

P11149, a derivative of Galanthamine, acts as a competitive, orally active, and selective AChE inhibitor with the ability to weakly penetrate the blood-brain barrier (BBB). It demonstrates selective inhibition, exhibiting an IC50 of 1.3 μM for rat BChE/AChE, and shows central cholinergic activity, behavioral efficacy, and safety. P11149 is utilized in Alzheimer's disease research[1].

P11149

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Catalog No. T38005Cas No. 164724-79-2

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,310	8-10 weeks	8-10 weeks
50 mg	$1,710	8-10 weeks	8-10 weeks
100 mg	$2,590	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	P11149, a derivative of Galanthamine, acts as a competitive, orally active, and selective AChE inhibitor with the ability to weakly penetrate the blood-brain barrier (BBB). It demonstrates selective inhibition, exhibiting an IC50 of 1.3 μM for rat BChE/AChE, and shows central cholinergic activity, behavioral efficacy, and safety. P11149 is utilized in Alzheimer's disease research[1].
Targets&IC50	BChE/AChE (rat):1.3 μM (IC50)
In vivo	P11149 is a GAL analog that, upon rapid in vivo hydrolyzation, produces 6-DMG, a potent AChE inhibitor. It demonstrates superior subcutaneous (s.c.) bioavailability compared to oral (p.o.) administration. In mice, oral doses of P11149 induce salivation (Sal), lacrimation (Lac), and tremors at levels comparable to those observed in rats. Notably, 6-DMG, P1 1012, and GAL trigger Sal and Lac at lower doses in rats. Moreover, P11149 has a half-life (T1/2(el)) of 2.4 hours and reaches a maximum concentration (Cmax) of 585 ng/mL in rat plasma.

Chemical Properties

Molecular Weight	472.02
Formula	C₂₇H₃₄ClNO₄
Cas No.	164724-79-2
Smiles	Cl.CN1CC[C@@]23C=C[C@H](O)C[C@@H]2Oc2c3c(C1)ccc2OC(=O)C12CC3CC(CC(C3)C1)C2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (211.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (10.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1186 mL	10.5928 mL	21.1855 mL	105.9277 mL
5 mM	0.4237 mL	2.1186 mL	4.2371 mL	21.1855 mL
10 mM	0.2119 mL	1.0593 mL	2.1186 mL	10.5928 mL
20 mM	0.1059 mL	0.5296 mL	1.0593 mL	5.2964 mL
50 mM	0.0424 mL	0.2119 mL	0.4237 mL	2.1186 mL
100 mM	0.0212 mL	0.1059 mL	0.2119 mL	1.0593 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

P-11149P11149P 11149

P11149

P11149

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In Vivo Formulation Calculator (Clear solution)

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