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Co-stimulatory Immune Checkpoint Proteins

Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.

FilterHomeRecombinant ProteinsImmune Checkpoint ProteinsCo-stimulatory Immune Checkpoint Proteins
  • CD40 Ligand Trimer Protein, Human, Recombinant (hFc)
    TMPK-01398
    CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells.
    • $418
    Backorder
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    TargetMol | Inhibitor Sale
  • CD28 Protein, Mouse, Recombinant (hFc & His)
    TMPJ-00099
    T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals, which are required for their activation. It is the receptor for CD80 and CD86. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. It involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
    • $35
    7-10 days
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  • SLAMF2 Protein, Mouse, Recombinant (His)
    TMPJ-00128
    CD48 is a GPI-linked protein in the CD2 family of immunoglobulin superfamily proteins. CD48 is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. Among dendritic cells (DC), CD48 is selectively expressed on circulating myeloid DC and resident bone marrow and thymus DC. CD2, 2B4, and heparan sulfate function as CD48 ligands. CD48 is competent to transduce signals and can also trigger signaling through CD2 or 2B4. CD48 expressed on NK cells is coactivating, whereas CD48 expressed on other cell types inhibits NK cell activation.
    • $116
    7-10 days
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  • 4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (His & Flag)
    TMPJ-00138
    4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 30 KDa and the accession number is P41273.
    • $86
    7-10 days
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  • CD27/TNFRSF7 Protein, Human, Recombinant (hFc & His)
    TMPJ-00421
    CD27 antigen is also known as CD27L receptor, T-cell activation antigen CD27, Tumor necrosis factor receptor superfamily member 7, T14 and TNFRSF7. In humans, it is encoded by the CD27 gene. CD27 is a single-pass type I membrane protein with 3 TNFR-Cys repeats. It is a member of the TNF-receptor superfamily and is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. It plays a role in survival of activated T-cells and apoptosis through association with SIVA1.
    • $47
    7-10 days
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  • ILDR2 Protein, Human, Recombinant (His)
    TMPJ-00353
    ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasis. The human ILDR2 lumenal domain shares a 99% and 98% homology with the mouse and rat respectively. The human gene encoding ILDR2 is located in a region on Chr1q23–25 that has been associated with type 2 diabetes. ILDR2 plays critical roles in hepatic clearance of lipoproteins and in lipid homeostasis. ILDR2 regulates human dendritic cells (DC2 cells, a subpopulation of polarized DCs that promotes Th2 differentiation). Recent publications reported that ILDR2 displayed negative regulatory functions on human and mouse T cells in various experimental systems. Fusion protein of ILDR2 lumenal domain with an Fc fragment, displays therapeutic effects in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA). ILDR2 represents a novel B7-like ligand that exerts negative immune modulation via interaction with a putative counterpart receptor expressed on activated T cells.
    • $86
    7-10 days
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  • OX40/TNFRSF4 Protein, Mouse, Recombinant (His)
    TMPJ-00422
    OX40/TNFRSF4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 40 KDa and the accession number is P47741.
    • $116
    7-10 days
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  • CD40 Protein, Cynomolgus, Recombinant (His)
    TMPJ-00634
    CD40 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 28-30 KDa and the accession number is G7PG38.
    • $116
    7-10 days
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  • CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi), Biotinylated
    TMPK-00111
    CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 18.2 kDa and the accession number is P10747.
    • $814
    7-10 days
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  • GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His)
    TMPK-00133
    GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 15.4 kDa and the accession number is Q9Y5U5-1.
    • $418
    7-10 days
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  • CD27 Ligand/CD70 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
    TMPK-00080
    CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7.  CD70 is a cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. CD27 Ligand/CD70 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 51.8 kDa and the accession number is P32970-1.
    • $814
    7-10 days
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  • B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
    TMPK-00314
    B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.5 kDa and the accession number is Q5ZPR3-1.
    • $418
    7-10 days
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  • CD155/PVR Protein, Human, Recombinant (His & Avi)
    TMPK-00260
    CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tumor-associated antigen. CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the poliovirus receptor, or PVR.
    • $371
    7-10 days
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  • OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated
    TMPK-00168
    Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 23.2 kDa and the accession number is P43489.
    • $814
    7-10 days
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  • OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi)
    TMPK-00463
    Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.2 kDa and the accession number is P47741.
    • $324
    7-10 days
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  • GITR/TNFRSF18 Protein, Mouse, Recombinant (aa 22-153, His)
    TMPK-01086
    GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. GITR/TNFRSF18 Protein, Mouse, Recombinant (aa 22-153, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 15.2 kDa and the accession number is Q8C4K3.
    • $418
    7-10 days
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  • CD28 Protein, Canine, Recombinant (His)
    TMPK-01176
    CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. CD28 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 16.7 kDa and the accession number is Q9GKP3.
    • $465
    7-10 days
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  • B7-H3 Protein, Human, Recombinant (aa 29-245, hFc)
    TMPK-01017
    B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 Protein, Human, Recombinant (aa 29-245, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 50.1 kDa and the accession number is Q5ZPR3-2.
    • $371
    7-10 days
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  • CD40L Protein, Rhesus macaque, Recombinant (His)
    TMPH-02439
    CD40L Protein, Rhesus macaque, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.5 kDa and the accession number is P63304.
    • $360
    20 days
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  • CD40 Ligand Protein, Rabbit, Recombinant (E. coli, His)
    TMPH-03200
    N/A. CD40 Ligand Protein, Rabbit, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.2 kDa and the accession number is G1SKP7.
    • $360
    20 days
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  • CD226 Protein, Rat, Recombinant (His)
    TMPY-00070
    CD226 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28 kDa and the accession number is A6K5P0.
    • $357
    7-10 days
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  • CD155/PVR Protein, Mouse, Recombinant (His)
    TMPY-00762
    CD155/PVR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28 kDa and the accession number is Q8K094.
    • $600
    7-10 days
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  • 4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (His)
    TMPY-00959
    4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is P41274.
    • $383
    7-10 days
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  • CD70 Protein, Human, Recombinant (hFc)
    TMPY-01068
    CD70 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.5 kDa and the accession number is A0A0U5JA32.
    • $296
    In Stock
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  • CD27/TNFRSF7 Protein, Mouse, Recombinant (His)
    TMPY-01432
    CD27/TNFRSF7 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.6 kDa and the accession number is P41272.
    • $700
    7-10 days
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  • 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His)
    TMPY-01743
    4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.8 kDa and the accession number is Q07011.
    • $222
    In Stock
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  • CD27/TNFRSF7 Protein, Mouse, Recombinant (His & hFc)
    TMPY-01378
    CD27/TNFRSF7 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is P41272.
    • $700
    7-10 days
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  • CD40 Ligand Protein, Mouse, Recombinant (hFc)
    TMPY-02793
    CD40 Ligand Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is P27548.
    • $258
    7-10 days
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  • CD70 Protein, Rat, Recombinant (hFc)
    TMPY-03129
    CD70 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is D3ZGU3.
    • $539
    7-10 days
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  • CD48 Protein, Rat, Recombinant (His)
    TMPY-03089
    CD48 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.9 kDa and the accession number is P10252.
    • $600
    7-10 days
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  • ICOS Protein, Rat, Recombinant (hFc)
    TMPY-03311
    ICOS Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.7 kDa and the accession number is Q9R1T7-1.
    • $600
    7-10 days
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  • 4-1BB Ligand/TNFSF9 Protein, Rat, Recombinant (hFc)
    TMPY-02992
    4-1BB Ligand/TNFSF9 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.9 kDa and the accession number is Q80WE6.
    • $462
    7-10 days
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  • CD40 Ligand Protein, Rhesus, Recombinant (hFc)
    TMPY-03542
    CD40 Ligand Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.7 kDa and the accession number is A0A8J8XRR8.
    • $462
    7-10 days
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  • OX40L/TNFSF4 Protein, Cynomolgus, Recombinant (mFc)
    TMPY-03875
    OX40L/TNFSF4 Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42 kDa and the accession number is F7FL80.
    • $306
    7-10 days
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  • CD40 Protein, Canine, Recombinant (His)
    TMPY-04089
    CD40 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and the accession number is Q7YRL5.
    • $600
    7-10 days
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  • CD28 Protein, Rat, Recombinant (His)
    TMPY-04252
    CD28 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.4 kDa and the accession number is A6IPD4.
    • $801
    7-10 days
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  • B7-H6 Protein, Human, Recombinant (His)
    TMPY-04619
    B7-H6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.1 kDa and the accession number is Q68D85.
    • $357
    7-10 days
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  • OX40/TNFRSF4 Protein, Rhesus, Recombinant (hFc)
    TMPY-04718
    OX40/TNFRSF4 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47 kDa and the accession number is A0A5F7ZEC3.
    • $398
    7-10 days
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  • BTN3A2 Protein, Human, Recombinant (His)
    TMPY-04779
    The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T cells. BTN3A2 is overexpressed in gastric tumors, and deletion of BTN3A2 inhibited proliferation, migration, and invasion of gastric cancer cells. The butyrophilin 3 (BTN3) receptors are implicated in the T lymphocytes regulation and present a wide plasticity in mammals. A thorough phylogenetic analysis reveals a concerted evolution of BTN3 characterized by a strong and recurrent homogenization of the region encoding the signal peptide and the immunoglobulin variable (IgV) domain in Hominoids, where the sequences of BTN3A1 or BTN3A3 are replaced by BTN3A2 sequence.
    • $386
    In Stock
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  • 4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (soluble form, rFc)
    TMPY-04995
    4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (soluble form, rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 46.1 kDa.
    • $600
    7-10 days
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  • CD27/TNFRSF7 Protein, Human, Recombinant (His), Biotinylated
    TMPY-04951
    CD27/TNFRSF7 Protein, Human, Recombinant (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.77 kDa and the accession number is P26842.
    • $197
    In Stock
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  • OX40L/TNFSF4 Protein, Mouse, Recombinant (rFc)
    TMPY-04980
    OX40L/TNFSF4 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 44.4 kDa and the accession number is B6DXE3.
    • $357
    7-10 days
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  • CD70 Protein, Human, Recombinant (rFc)
    TMPY-04982
    CD70 Protein, Human, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 44.6 kDa and the accession number is A0A0U5JA32.
    • $539
    7-10 days
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  • DNAM-1/CD226 Protein, Human, Recombinant (His), Biotinylated
    TMPY-05226
    CD226 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.4 kDa and the accession number is Q15762.
    • $306
    7-10 days
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  • CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated
    TMPY-05354
    CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 43.7 kDa and the accession number is P10747-1.
    • $234
    In Stock
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  • 4-1BB Ligand/TNFSF9 Protein, Cynomolgus, Recombinant (hFc), Biotinylated
    TMPY-05506
    4-1BB Ligand/TNFSF9 Protein, Cynomolgus, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.8 kDa and the accession number is XP_015296398.1.
    • $383
    7-10 days
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  • CD40 Protein, Human, Recombinant (hFc & Avi), Biotinylated
    TMPY-05599
    CD40 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 47.7 kDa and the accession number is A0A0S2Z3C7.
    • $462
    7-10 days
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  • CD155/PVR Protein, Mouse, Recombinant (mFc)
    TMPY-05791
    CD155/PVR Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 60.78 kDa and the accession number is Q8K094.
    • $357
    In Stock
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  • ICOS Protein, Mouse, Recombinant (His)
    TMPY-06209
    ICOS Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.9 kDa and the accession number is Q5SUZ7.
    • $600
    7-10 days
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  • CD155/PVR Protein, Human, Recombinant (hFc & Avi), Biotinylated
    TMPY-06133
    CD155/PVR Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 63.6 kDa and the accession number is P15151-1.
    • $462
    7-10 days
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