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Anti-IL-6R Antibody-APC (5L295)
🥰Excellent
Catalog No. TMAY-00760A
Anti-IL-6R Antibody-APC (5L295) is a APC-conjugated Mouse antibody targeting IL-6R. Anti-IL-6R Antibody-APC (5L295) can be used in FCM.
Anti-IL-6R Antibody-APC (5L295)
Anti-IL-6R Antibody-APC (5L295)
🥰Excellent
Catalog No. TMAY-00760A
Anti-IL-6R Antibody-APC (5L295) is a APC-conjugated Mouse antibody targeting IL-6R. Anti-IL-6R Antibody-APC (5L295) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IL-6R Antibody-APC (5L295) is a APC-conjugated Mouse antibody targeting IL-6R. Anti-IL-6R Antibody-APC (5L295) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 5L295 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human IL-6R expression on U266 cells. Cells were stained with APC-conjugated anti-Human IL-6R. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-6R / CD126 (rh IL-6R / CD126; TMPY-00864; NP_000556.1; Met1-Pro365). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a SIL-6R protein can mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signaling. Through this so-called 'trans-signaling' mechanism, IL-6 can stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | APC |
| Others Formats | Unconjugated/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human IL-6R / CD126 protein (TMPY-00864) |
| Antigen Species | Human |
| Biology Area | Neuroinflammation |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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