Shopping Cart

Your shopping cart is currently empty

Pteridine-2,4(1H,3H)-dione

Name: Pteridine-2,4(1H,3H)-dione
Brand: TargetMol
SKU: T4857
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T4857Cas No. 487-21-8

Alias Lumazine, 2,4-Dihydroxypteridine

Pteridine-2,4(1H,3H)-dione (Lumazine) is an innovative MALDI matrix for analyzing complex (phospho)lipid mixtures.

Pteridine-2,4(1H,3H)-dione

Copy Product Info

😃Good

Purity: 99.56%

Catalog No. T4857Alias Lumazine, 2,4-DihydroxypteridineCas No. 487-21-8

Pteridine-2,4(1H,3H)-dione (Lumazine) is an innovative MALDI matrix for analyzing complex (phospho)lipid mixtures.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$31	In Stock	In Stock
500 mg	$64	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.56%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Pteridine-2,4(1H,3H)-dione AI Summary

Pteridine-2,4(1H,3H)-dione exhibits cytotoxicity against human THLE cells, demonstrated by ATP depletion in CellTitre-Glo assays at 72 hours, 24 hours, and 4 hours, with an EC50 value greater than 300000.0 nM. The compound also induces the generation of reactive oxygen species (ROS), specifically H2O2, measured as the oxidation of phenol red after 60 minutes, with an EC50 value of 713000.0 nM. Furthermore, Pteridine-2,4(1H,3H)-dione shows less than 25% inhibition of wild type PI3K p110alpha/p85alpha and full-length PI3Kalpha, leading to a reduction in PIP3 formation at 100 uM using PIP2 as a substrate after 45 minutes by fluorescence polarization assay relative to control..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pteridine-2,4(1H,3H)-dione (Lumazine) is an innovative MALDI matrix for analyzing complex (phospho)lipid mixtures.
Synonyms	Lumazine, 2,4-Dihydroxypteridine

Chemical Properties

Molecular Weight	164.12
Formula	C₆H₄N₄O₂
Cas No.	487-21-8
Smiles	O=c1[nH]c2nccnc2c(=O)[nH]1
Relative Density.	1.522 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (365.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0931 mL	30.4655 mL	60.9310 mL	304.6551 mL
5 mM	1.2186 mL	6.0931 mL	12.1862 mL	60.9310 mL
10 mM	0.6093 mL	3.0466 mL	6.0931 mL	30.4655 mL
20 mM	0.3047 mL	1.5233 mL	3.0466 mL	15.2328 mL
50 mM	0.1219 mL	0.6093 mL	1.2186 mL	6.0931 mL
100 mM	0.0609 mL	0.3047 mL	0.6093 mL	3.0466 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc