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KA2507 monohydrochloride

Catalog No. T61322

KA2507 hydrochloride is a powerful and specific HDAC6 inhibitor, possessing an IC50 value of 2.5 nM. It displays no substantial toxicities while demonstrating significant antitumor efficacy and immune modulatory effects [1].

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KA2507 monohydrochloride Chemical Structure

KA2507 monohydrochloride, CAS N/A

Pack Size	Availability	Price/USD	Quantity
25 mg	10-14 weeks	Inquiry

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description	KA2507 hydrochloride is a powerful and specific HDAC6 inhibitor, possessing an IC50 value of 2.5 nM. It displays no substantial toxicities while demonstrating significant antitumor efficacy and immune modulatory effects [1].
In vitro	KA2507 hydrochloride does not prevent the proliferation of mouse or human cancer cells at selective concentrations for HDAC6 inhibition in vitro. Anti-proliferative effects manifest only at higher concentrations of KA2507 hydrochloride, accompanied by heightened acetylation of histone H3, indicating that these effects are due to off-target inhibition of class I HDAC and HDAC6 [1].
In vivo	KA2507 hydrochloride, administered orally at doses between 100-200 mg/kg daily for 20 days, demonstrated significant inhibition of tumor growth in the syngeneic B16-F10 mouse melanoma model and showed antitumor efficacy in CT26 and MC38 colorectal cancer models. This compound not only reduced STAT3 activation (indicated by decreased phospho-STAT3 levels) - a crucial suppressor of antitumor immune responses - but also lowered PD-L1 expression and increased MHC class I expression, highlighting its potential in modulating antitumor immunity. However, KA2507 hydrochloride exhibited limited oral bioavailability (15% in mice) and a maximum concentration (Cmax) of 300 ng/mL at a dosage of 200 mg/kg. This pharmacokinetic profile was established through studies in male C57BL/6 mice utilizing the B16-F10 melanoma model.

Molecular Weight	358.78
Formula	C16H15ClN6O2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KA2507 monohydrochloride inhibitor inhibit

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