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Anti-FLRT1 Antibody (4M341)

😃Good
Catalog No. TMAY-01853
Alias SPG68, fibronectin leucine rich transmembrane protein 1

Anti-FLRT1 Antibody (4M341) is a Mouse antibody targeting FLRT1. Anti-FLRT1 Antibody (4M341) can be used in ELISA.

Anti-FLRT1 Antibody (4M341)

Anti-FLRT1 Antibody (4M341)

😃Good
Catalog No. TMAY-01853Alias SPG68, fibronectin leucine rich transmembrane protein 1
Anti-FLRT1 Antibody (4M341) is a Mouse antibody targeting FLRT1. Anti-FLRT1 Antibody (4M341) can be used in ELISA.
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100 μL$198 7-10 days
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Product Introduction

Bioactivity
Description
Anti-FLRT1 Antibody (4M341) is a Mouse antibody targeting FLRT1. Anti-FLRT1 Antibody (4M341) can be used in ELISA.
AliasSPG68, fibronectin leucine rich transmembrane protein 1
Ig Type
Monoclonal Mouse IgG1
Clone
4M341
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human FLRT1 (rh FLRT1; TMPY-02032; Q9NZU1-1; Met 1-Pro 524). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundThe three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT1 is expressed in kidney and brain, which is a target for tyrosine phosphorylation mediated by FGFR1 and implicates a non-receptor Src family kinase (SFK). All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. The phosphorylation state of FLRT1, which is itself FGFR1 dependent, may play a critical role in the potentiation of FGFR1 signalling and may also depend on a SFK-dependent phosphorylation mechanism acting via the FGFR. This is consistent with an 'in vivo' role for FLRT1 regulation of FGF signalling via SFKs. Furthermore, the phosphorylation-dependent futile cycle mechanism controlling FGFR1 signalling is concurrently crucial for regulation of FLRT1-mediated neurite outgrowth. FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. FLRT3 shares 55% amino acid sequence identity with FLRT1.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human FLRT1 protein (TMPY-02032)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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