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TFIIH Modulator-19
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Catalog No. T21083Cas No. 363-03-1
Alias TFIIH Modulator19, TFIIH Modulator 19
TFIIH Modulator-19 induces the dimerization of trichothiodystrophy group A protein to modulate TFIIH transcriptional activity.
TFIIH Modulator-19
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Purity: 99.01%
Catalog No. T21083Alias TFIIH Modulator19, TFIIH Modulator 19Cas No. 363-03-1
TFIIH Modulator-19 induces the dimerization of trichothiodystrophy group A protein to modulate TFIIH transcriptional activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $41 | In Stock | In Stock | |
| 1 g | $56 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.01%
Appearance:Solid
Color:Yellow
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Product Introduction
TFIIH Modulator-19 AI Summary
TFIIH Modulator-19 is a potent inhibitor of thymidylate synthetase, demonstrating varying rates of kobs for enzyme inactivation at different doses, measured at pH 6.8 and 30°C. It effectively lowers the substrate concentration required for thymidylate synthetase inactivation, suggesting strong bioactivity against this target enzyme. Additionally, TFIIH Modulator-19 has a bioactivity rate constant of k2 = 2600.0 M-1 s-1 in Acetonitrile and buffered aqueous acetonitrile solution under the same conditions. It shows low glutathione reactivity, with activity levels of 8.0% and 21.0% in the presence of glutathione and EDTA buffer at pH 7.4, assessed via Ellman's method. Furthermore, TFIIH Modulator-19 inhibits the recombinant Clostridium botulinum neurotoxin serotype A light chain with a Kinact/KI ratio of 9.7 /M/s in a SNAPtide FRET-based assay at 50 µM concentration over 1.5 hours. It also exhibits moderate potency in inhibiting monoamine oxidase enzymes, with IC50 values of 5030.0 nM for MAO-A and 7870.0 nM for MAO-B, showing reversible inhibition of MAO-A and irreversible inhibition of both MAO-A and MAO-B at higher concentrations, with a slightly higher potency towards MAO-A. These findings highlight TFIIH Modulator-19's potential in biochemical and pharmacological applications as a potent inhibitor of thymidylate synthetase and a moderate MAO inhibitor..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TFIIH Modulator-19 induces the dimerization of trichothiodystrophy group A protein to modulate TFIIH transcriptional activity. |
| Synonyms | TFIIH Modulator19, TFIIH Modulator 19 |
| Molecular Weight | 184.19 |
| Formula | C12H8O2 |
| Cas No. | 363-03-1 |
| Smiles | O=C1C=CC(=O)C(=C1)C1=CC=CC=C1 |
| Relative Density. | 1.1336 g/cm3 (Estimated) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 1.85 mg/mL (10.04 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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