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Anti-Siglec-2/CD22 Antibody (3K71)

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Catalog No. TMAH-00182
Alias SIGLEC-2, SIGLEC2, CD22 molecule

Anti-Siglec-2/CD22 Antibody (3K71) is an antibody targeting Siglec-2/CD22. Anti-Siglec-2/CD22 Antibody (3K71) can be used in ELISA, IHC.

Anti-Siglec-2/CD22 Antibody (3K71)

Anti-Siglec-2/CD22 Antibody (3K71)

😃Good
Catalog No. TMAH-00182Alias SIGLEC-2, SIGLEC2, CD22 molecule
Anti-Siglec-2/CD22 Antibody (3K71) is an antibody targeting Siglec-2/CD22. Anti-Siglec-2/CD22 Antibody (3K71) can be used in ELISA, IHC.
Pack SizePriceAvailabilityQuantity
50 μL$209 7-10 days
100 μL$349 7-10 days
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Product Introduction

Bioactivity
Description
Antibody Type: Recombinant Rabbit Monoclonal

Application: ELISA, IHC

Reactivity: Human
AliasSIGLEC-2, SIGLEC2, CD22 molecule
Ig Type
Rabbit IgG
Clone
3K71
Reactivity
Human
Verified Activity
IHC image of TMAH-00182 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Application
ELISA, IHC
Recommended Dose
IHC:1:50-1:200.
Antibody Type
Monoclonal
Subcellular LocalizationCell membrane; Single-pass type I membrane protein.
ConstructionRecombinant Antibody
PurificationAffinity-chromatography
AppearanceLiquid
FormulationPhosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundMediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
A synthetic peptide: Human CD22
Antigen Species
Human
Gene ID
933
Uniprot ID
Biology Area
Cancer, Immunology, Stem cells
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

Sci Citations

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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