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Anti-S100A1 Antibody (1A890) is a Rabbit antibody targeting S100A1. Anti-S100A1 Antibody (1A890) can be used in IHC-P.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μL | $269 | 7-10 days |
Description | Anti-S100A1 Antibody (1A890) is a Rabbit antibody targeting S100A1. Anti-S100A1 Antibody (1A890) can be used in IHC-P. |
Alias | S100a, S100 calcium binding protein A1, S100, AI266795 |
Ig Type | Monoclonal Rabbit IgG |
Clone | 1A890 |
Reactivity | Mouse |
Verified Activity | 1. Immunochemical staining of mouse S100A1 in mouse heart with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human mouse S100A1 in mouse bone with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to chondrocyte. |
Application | IHC-P |
Recommended Dose | IHC-P: 1:100-1:500 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse S100A1 (rM S100A1; TMPY-02532; P56565; Gly2-Ser94). |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | S100A1 is a Ca2+binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+release, inhibition of microtubule assembly, and inhibition of PKC-mediated phosphorylation. Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S100A1, and recently, S100A1 is also identified as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex. S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility. Accordingly, reduced expression or mutations of S100A1 gene have been implicated in cardiomyopathies. |
Conjucates | Unconjugated |
Immunogen | Recombinant Mouse S100A1 protein (TMPY-02532) |
Antigen Species | Mouse |
Biology Area | Calcium-binding Proteins and Related Molecules |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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