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Anti-Phospho-SGK1 (Ser78) Polyclonal Antibody 2
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Catalog No. TMAB-11274
Anti-Phospho-SGK1 (Ser78) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-SGK1 (Ser78). Anti-Phospho-SGK1 (Ser78) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF.
Anti-Phospho-SGK1 (Ser78) Polyclonal Antibody 2
Anti-Phospho-SGK1 (Ser78) Polyclonal Antibody 2
😃Good
Catalog No. TMAB-11274
Anti-Phospho-SGK1 (Ser78) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-SGK1 (Ser78). Anti-Phospho-SGK1 (Ser78) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-SGK1 (Ser78) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-SGK1 (Ser78). Anti-Phospho-SGK1 (Ser78) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Isoform 2: Cell membrane.Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Nuclear, upon phosphorylation. |
| Tissue Specificity | Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and skeletal muscle. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | SGK1 is a protein kinase that plays an important role in cellular stress response. SGK1 activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels of SGK1 and activity may contribute to conditions such as hypertension and diabetic nephropathy. This protein also mediates cell survival signals, as it has been shown to phosphorylate and negatively regulate the pro apoptotic FOXO3A protein. Ser 422 is a critical site on the protein and may be involved in its activation. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human SGK1 around the phosphorylation site of Ser78 |
| Antigen Species | Human |
| Gene Name | SGK1 |
| Gene ID | |
| Protein Name | Serine/threonine-protein kinase Sgk1 |
| Uniprot ID | |
| Function | Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1. |
| Molecular Weight | Theoretical: 49 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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