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INCB 3284

Name: INCB 3284
Brand: TargetMol
SKU: T11648
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11648Cas No. 887401-92-5

INCB 3284 is an orally available, selective and high affinity chemokine receptor 2 (CCR2) antagonist that inhibits monocyte chemotactic protein 1 from interacting with hCCR2.INCB 3284 is used in the study of hemorrhagic shock.

INCB 3284

🥰Excellent

Purity: 99.42%

Catalog No. T11648Cas No. 887401-92-5

Pack Size	Price	Availability
2 mg	$33	In Stock
5 mg	$51	In Stock
10 mg	$81	In Stock
25 mg	$137	In Stock
50 mg	$196	In Stock
100 mg	$296	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.42%

ee:100%

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COA CSFC HNMR LCMS ORP

Product Introduction

Bioactivity

Description	INCB 3284 is an orally available, selective and high affinity chemokine receptor 2 (CCR2) antagonist that inhibits monocyte chemotactic protein 1 from interacting with hCCR2.INCB 3284 is used in the study of hemorrhagic shock.
Targets&IC50	MCP-1-hCCR2:3.7 nM, K+ channel (hERG):84 μM
In vitro	INCB3284 exhibited an IC50 of 3.7 nM for antagonizing the binding of monocyte chemoattractant protein-1 to hCCR2, an IC50 of 4.7 nM for antagonizing chemotactic activity, and an IC50 of 84 μM for inhibiting hERG potassium currents[1].
In vivo	INCB 3284 (1 mg/kg/day, intraperitoneal injection) or C021 significantly improved the neurological outcomes in AOM-treated mice, reduced microglial activation, decreased phosphorylation of ERK1/2, and attenuated the upregulation of cytokines induced by AOM[2].

Chemical Properties

Molecular Weight	520.54
Formula	C₂₆H₃₁F₃N₄O₄
Cas No.	887401-92-5
Smiles	COc1ccc(cn1)[C@@]1(O)CC[C@@H](CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 60 mg/mL (115.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9211 mL	9.6054 mL	19.2108 mL	96.0541 mL
5 mM	0.3842 mL	1.9211 mL	3.8422 mL	19.2108 mL
10 mM	0.1921 mL	0.9605 mL	1.9211 mL	9.6054 mL
20 mM	0.0961 mL	0.4803 mL	0.9605 mL	4.8027 mL
50 mM	0.0384 mL	0.1921 mL	0.3842 mL	1.9211 mL
100 mM	0.0192 mL	0.0961 mL	0.1921 mL	0.9605 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc