Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Antiproliferative Agent-17 exhibits both antimicrobial properties against Gram-positive bacteria and anticancer activity [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Antiproliferative Agent-17 exhibits both antimicrobial properties against Gram-positive bacteria and anticancer activity [1]. |
In vitro | Antiproliferative agent-17 (compound 5e) exhibited activity against Gram-positive bacteria, including Staphylococcus aureus IFO 3060, Bacillus subtilis IFO 3007, and Micrococcus luteus IFO 3232. It showed no activity against the tested Gram-negative bacteria and fungi [1]. Compound 5e demonstrated antiproliferative effects with IC50 values of 12.85 μM for PC-3 (human prostate cancer), 11.96 μM for HCT-116 (human colorectal cancer), 16.30 μM for HepG-2 (human hepatocellular carcinoma), 9.87 μM for HeLa (human cervical cancer), and 6.90 μM for MCF-7 (human breast cancer) [1]. Additionally, it binds to the active site of the SIRT1 enzyme, occupying the positions of the NAD cofactor and the known histone deacetylase inhibitor EX527 [1]. |
Molecular Weight | 416.58 |
Formula | C26H28N2OS |
CAS No. | 2882206-08-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Antiproliferative agent-17 2882206-08-6 inhibitor inhibit