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TML-6

Name: TML-6
Brand: TargetMol
SKU: T37148
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37148Cas No. 1462868-88-7

Alias TML6

TML-6 is an orally available curcumin derivative that inhibits synthesis of β-amyloid (Aβ) and Aβ precursor protein, upregulates Apo E, activates Nrf2, suppresses NF-κB and mTOR, and ameliorates inflammation. It is suitable for Alzheimer's disease research.

TML-6

🥰Excellent

Purity: 99.71%

Catalog No. T37148Alias TML6Cas No. 1462868-88-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
5 mg	$247	-	In Stock
10 mg	$396	-	In Stock
25 mg	$787	-	In Stock
50 mg	$1,180	-	In Stock
100 mg	$1,860	-	In Stock
1 mL x 10 mM (in DMSO)	$285	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.71%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TML-6 is an orally available curcumin derivative that inhibits synthesis of β-amyloid (Aβ) and Aβ precursor protein, upregulates Apo E, activates Nrf2, suppresses NF-κB and mTOR, and ameliorates inflammation. It is suitable for Alzheimer's disease research.
In vitro	TML-6 exhibits no toxicity to Huh-7 cells at concentrations below 5 μM, with an IC50 value of 4.19 μg/mL. TML-6 significantly activates the Nrf2 gene at a concentration of 1.32 μg/mL [1].
In vivo	TML-6 (dietary, 150 mg/kg/day for four months) improved Aβ levels and Iba-1 expression in the brains of 3xTg (mutations: APPKM670/671NL, MAPTP301L, and PSEN1M146V) AD transgenic mice, significantly reducing their learning behavior [1]. After oral administration of 150 mg/kg TML-6 in SD rats, the plasma concentration of TML-6 reached a peak C-max of 35.9±15.6 ng/mL, with a T-max of 3.67±2.08 hours [1].
Synonyms	TML6

Chemical Properties

Molecular Weight	523.62
Formula	C₃₀H₃₇NO₇
Cas No.	1462868-88-7
Smiles	CCN(CC)C(=O)CC(C)(C(=O)\C=C\c1ccc(OC)c(OC)c1)C(=O)\C=C\c1ccc(OC)c(OC)c1
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (181.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9098 mL	9.5489 mL	19.0978 mL	95.4891 mL
5 mM	0.3820 mL	1.9098 mL	3.8196 mL	19.0978 mL
10 mM	0.1910 mL	0.9549 mL	1.9098 mL	9.5489 mL
20 mM	0.0955 mL	0.4774 mL	0.9549 mL	4.7745 mL
50 mM	0.0382 mL	0.1910 mL	0.3820 mL	1.9098 mL
100 mM	0.0191 mL	0.0955 mL	0.1910 mL	0.9549 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc