Shopping Cart

Your shopping cart is currently empty

TML-6

Name: TML-6
Brand: TargetMol
SKU: T37148
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T37148Cas No. 1462868-88-7

Alias TML6

TML-6 is an orally available curcumin derivative that inhibits synthesis of β-amyloid (Aβ) and Aβ precursor protein, upregulates Apo E, activates Nrf2, suppresses NF-κB and mTOR, and ameliorates inflammation. It is suitable for Alzheimer's disease research.

TML-6

Copy Product Info

😃Good

Purity: 99.71%

Catalog No. T37148Alias TML6Cas No. 1462868-88-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
5 mg	$247	-	In Stock
10 mg	$396	-	In Stock
25 mg	$787	-	In Stock
50 mg	$1,180	-	In Stock
100 mg	$1,860	-	In Stock
1 mL x 10 mM (in DMSO)	$285	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.71%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	TML-6 is an orally available curcumin derivative that inhibits synthesis of β-amyloid (Aβ) and Aβ precursor protein, upregulates Apo E, activates Nrf2, suppresses NF-κB and mTOR, and ameliorates inflammation. It is suitable for Alzheimer's disease research.
In vitro	TML-6 exhibits no toxicity to Huh-7 cells at concentrations below 5 μM, with an IC50 value of 4.19 μg/mL. TML-6 significantly activates the Nrf2 gene at a concentration of 1.32 μg/mL [1].
In vivo	TML-6 (dietary, 150 mg/kg/day for four months) improved Aβ levels and Iba-1 expression in the brains of 3xTg (mutations: APPKM670/671NL, MAPTP301L, and PSEN1M146V) AD transgenic mice, significantly reducing their learning behavior [1]. After oral administration of 150 mg/kg TML-6 in SD rats, the plasma concentration of TML-6 reached a peak C-max of 35.9±15.6 ng/mL, with a T-max of 3.67±2.08 hours [1].
Synonyms	TML6

Chemical Properties

Molecular Weight	523.62
Formula	C₃₀H₃₇NO₇
Cas No.	1462868-88-7
Smiles	CCN(CC)C(=O)CC(C)(C(=O)\C=C\c1ccc(OC)c(OC)c1)C(=O)\C=C\c1ccc(OC)c(OC)c1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (181.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9098 mL	9.5489 mL	19.0978 mL	95.4891 mL
5 mM	0.3820 mL	1.9098 mL	3.8196 mL	19.0978 mL
10 mM	0.1910 mL	0.9549 mL	1.9098 mL	9.5489 mL
20 mM	0.0955 mL	0.4774 mL	0.9549 mL	4.7745 mL
50 mM	0.0382 mL	0.1910 mL	0.3820 mL	1.9098 mL
100 mM	0.0191 mL	0.0955 mL	0.1910 mL	0.9549 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc