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Chlorahololide D
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Catalog No. TN5335Cas No. 943136-39-8
Chlorahololide D is a natural lindane-type sesquiterpene dimer and selective potassium channel blocker that stimulates reactive oxygen species ROS levels to cause cell cycle arrest in the G2 phase, modulates Bcl-2 and Bax and FAK, thereby inhibiting MCF-7 cell growth and triggering apoptosis. Chlorahololide D inhibits tumor proliferation, migration and angiogenesis in in vivo experiments and has anti-breast cancer potential.
Chlorahololide D
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Purity: 98.43%
Catalog No. TN5335Cas No. 943136-39-8
Chlorahololide D is a natural lindane-type sesquiterpene dimer and selective potassium channel blocker that stimulates reactive oxygen species ROS levels to cause cell cycle arrest in the G2 phase, modulates Bcl-2 and Bax and FAK, thereby inhibiting MCF-7 cell growth and triggering apoptosis. Chlorahololide D inhibits tumor proliferation, migration and angiogenesis in in vivo experiments and has anti-breast cancer potential.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $229 | - | In Stock | |
| 5 mg | $577 | - | In Stock | |
| 10 mg | $822 | - | In Stock | |
| 25 mg | $1,230 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.43%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Chlorahololide D is a natural lindane-type sesquiterpene dimer and selective potassium channel blocker that stimulates reactive oxygen species ROS levels to cause cell cycle arrest in the G2 phase, modulates Bcl-2 and Bax and FAK, thereby inhibiting MCF-7 cell growth and triggering apoptosis. Chlorahololide D inhibits tumor proliferation, migration and angiogenesis in in vivo experiments and has anti-breast cancer potential. |
| Targets&IC50 | Rat dissociated hippocampal neurons:2.7±0.3μM, MCF-7 cells:6.7 μM, HepG2 cells:13.7 μM |
| In vitro | Chlorahololides D exhibited potent and selective potassium channel blocking activity on the delayed rectifier (IK) K+ current in rat dissociated hippocampal neurons, with the IC50 values of 2.7±0.3μM.[1] Chlorahololide D exhibited potent cytotoxicity against MCF-7 breast cancer cells with an IC₅₀ of 6.7 μM, and moderate activity against HepG2 liver cancer cells (IC₅₀ = 13.7 μM).[2] |
| In vivo | In MCF-7 xenograft zebrafish models, Chlorahololide D (2.5–10 μM) significantly reduced tumor fluorescence intensity and the number of metastatic foci.[2] In transgenic zebrafish models, Chlorahololide D disrupted the formation of intersegmental vessels (ISVs) and dorsal longitudinal anastomotic vessels (DLAVs) in a dose-dependent manner (5–20 μM), indicating strong anti-angiogenic activity.[2] |
| Molecular Weight | 676.75 |
| Formula | C38H44O11 |
| Cas No. | 943136-39-8 |
| Smiles | C(\C(OC)=O)(/C)=C\1/[C@@]2([C@@]34[C@]([C@@]5(C)[C@]6([C@](C6)([C@](COC(/C(=C/C)/C)=O)(O)[C@@]5(CC3=C(COC(C)=O)C(=O)O4)[H])[H])[H])(CC7=C2[C@](C)([C@]8([C@@]7(C8)[H])[H])[C@@H](O)C1=O)[H])[H] |
| Relative Density. | 1.41 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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