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Chlorahololide D
🥰Excellent
Catalog No. TN5335Cas No. 943136-39-8
Chlorahololide D is a natural lindane-type sesquiterpene dimer and selective potassium channel blocker that stimulates reactive oxygen species ROS levels to cause cell cycle arrest in the G2 phase, modulates Bcl-2 and Bax and FAK, thereby inhibiting MCF-7 cell growth and triggering apoptosis. Chlorahololide D inhibits tumor proliferation, migration and angiogenesis in in vivo experiments and has anti-breast cancer potential.
Chlorahololide D
🥰Excellent
Purity: 98.43%
Catalog No. TN5335Cas No. 943136-39-8
Chlorahololide D is a natural lindane-type sesquiterpene dimer and selective potassium channel blocker that stimulates reactive oxygen species ROS levels to cause cell cycle arrest in the G2 phase, modulates Bcl-2 and Bax and FAK, thereby inhibiting MCF-7 cell growth and triggering apoptosis. Chlorahololide D inhibits tumor proliferation, migration and angiogenesis in in vivo experiments and has anti-breast cancer potential.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $229 | In Stock | |
| 5 mg | $577 | In Stock | |
| 10 mg | $822 | In Stock | |
| 25 mg | $1,230 | In Stock |
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Purity:98.43%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Chlorahololide D is a natural lindane-type sesquiterpene dimer and selective potassium channel blocker that stimulates reactive oxygen species ROS levels to cause cell cycle arrest in the G2 phase, modulates Bcl-2 and Bax and FAK, thereby inhibiting MCF-7 cell growth and triggering apoptosis. Chlorahololide D inhibits tumor proliferation, migration and angiogenesis in in vivo experiments and has anti-breast cancer potential. |
| Targets&IC50 | Rat dissociated hippocampal neurons:2.7±0.3μM, HepG2 cell:13.7 μM, MCF-7 cells:6.7 μM |
| In vitro | Chlorahololides D exhibited potent and selective potassium channel blocking activity on the delayed rectifier (IK) K+ current in rat dissociated hippocampal neurons, with the IC50 values of 2.7±0.3μM.[1] Chlorahololide D exhibited potent cytotoxicity against MCF-7 breast cancer cells with an IC₅₀ of 6.7 μM, and moderate activity against HepG2 liver cancer cells (IC₅₀ = 13.7 μM).[2] |
| In vivo | In MCF-7 xenograft zebrafish models, Chlorahololide D (2.5–10 μM) significantly reduced tumor fluorescence intensity and the number of metastatic foci.[2] In transgenic zebrafish models, Chlorahololide D disrupted the formation of intersegmental vessels (ISVs) and dorsal longitudinal anastomotic vessels (DLAVs) in a dose-dependent manner (5–20 μM), indicating strong anti-angiogenic activity.[2] |
| Molecular Weight | 676.75 |
| Formula | C38H44O11 |
| Cas No. | 943136-39-8 |
| Smiles | C(\C(OC)=O)(/C)=C\1/[C@@]2([C@@]34[C@]([C@@]5(C)[C@]6([C@](C6)([C@](COC(/C(=C/C)/C)=O)(O)[C@@]5(CC3=C(COC(C)=O)C(=O)O4)[H])[H])[H])(CC7=C2[C@](C)([C@]8([C@@]7(C8)[H])[H])[C@@H](O)C1=O)[H])[H] |
| Relative Density. | 1.41 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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