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β-catenin modulator IIa-661

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Catalog No. T67884Cas No. 1015859-04-7

β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.

β-catenin modulator IIa-661

β-catenin modulator IIa-661

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Purity: 99.58%
Catalog No. T67884Cas No. 1015859-04-7
β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$30-In Stock
5 mg$51-In Stock
10 mg$76-In Stock
25 mg$131-In Stock
50 mg$200-In Stock
100 mg$293-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.58%
Appearance:Solid
Color:White
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Product Introduction

β-catenin modulator IIa-661 AI Summary
β-catenin modulator IIa-661 exhibits a diverse range of bioactivities. It shows inhibitory activity against Schistosoma mansoni peroxiredoxins with a potency of 11,220.2 nM and influenza NS1 protein function with a potency of 7,943.3 nM. Additionally, it inhibits histone lysine methyltransferase G9a with a potency of 79,432.8 nM and mammalian selenoprotein thioredoxin reductase 1 (TrxR1) with a potency of 25,118.9 nM. Furthermore, it demonstrates inhibitory activity against TGF-β with a potency of 31,622.8 nM and acts as an antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2) with a potency of 89,125.1 nM. It also shows antiviral activity against the Foot and Mouth Disease Virus with a potency of 10,000.0 nM..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.
Chemical Properties
Molecular Weight394.92
FormulaC19H23ClN2O3S
Cas No.1015859-04-7
SmilesC(S(CC(NC1CCCCC1)=O)=O)C=2N=C(OC2C)C3=CC=C(Cl)C=C3
Relative Density.1.33 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 3.95 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5322 mL12.6608 mL25.3216 mL126.6079 mL
5 mM0.5064 mL2.5322 mL5.0643 mL25.3216 mL
10 mM0.2532 mL1.2661 mL2.5322 mL12.6608 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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