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HPPH
🥰Excellent
Catalog No. T15501Cas No. 149402-51-7
Alias Photochlor
HPPH (Photochlor) (Photochlor) is a second-generation photosensitizer. It is used as photodynamic therapy (PDT) agent.
HPPH
🥰Excellent
Purity: 99.72%
Catalog No. T15501Alias PhotochlorCas No. 149402-51-7
HPPH (Photochlor) (Photochlor) is a second-generation photosensitizer. It is used as photodynamic therapy (PDT) agent.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $60 | In Stock | |
| 2 mg | $88 | In Stock | |
| 5 mg | $147 | In Stock | |
| 10 mg | $263 | In Stock | |
| 25 mg | $455 | In Stock | |
| 50 mg | Preferential | In Stock | |
| 1 mL x 10 mM (in DMSO) | $197 | In Stock |
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Purity:99.72%
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Product Introduction
Bioactivity
Chemical Properties
| Description | HPPH (Photochlor) (Photochlor) is a second-generation photosensitizer. It is used as photodynamic therapy (PDT) agent. |
| In vitro | Cells treated with GO-PEG-HHPH displays a stronger fluorescence signal than those treated with free HPPH. In fact, the fluorescence of HPPH is rather weak. After 24 h, Fluorescence image of 4T1 cells incubated with 0.49 μg/mL GO-PEG, 1 μM HPPH (free HPPH), or equivalent amount of GO-PEG-HPPH (1 μM HPPH and 0.49 μg/mL GO-PEG). The cellular uptake of GO-PEG-HPPH and HPPH is investigated with 4T1 murine mammary cancer cells. The cells are incubated with GO-PEG-HPPH and free HPPH at equivalent HPPH concentration (1 μM) for 24 h and then observed with a confocal microscope [1]. |
| In vivo | A combination treatment regimen for Colo26-HA tumor-bearing BALB/c mice involves administering an HPPH-PDT (0.4 μmoles/kg HPPH followed by 665 nm light at 48 J/cm2) to enhance anti-tumor immunity. Following a 9-day rest period and an HPPH injection, tumors receive a control treatment with 665 nm light at 132 J/cm2 on day 10 [2]. |
| Synonyms | Photochlor |
| Molecular Weight | 636.82 |
| Formula | C39H48N4O4 |
| Cas No. | 149402-51-7 |
| Smiles | CCCCCCOC(C)c1c(C)c2\C=C3/N=C([C@@H](CCC(O)=O)[C@@H]3C)C3=C4NC(\C=c5/[nH]\c(=C/c1[nH]2)c(C)c5CC)C(C)=C4C(=O)C3 |
| Relative Density. | 1.184 g/cm3 |
| Color | Black |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (78.52 mM), Sonication is recommended. H2O: < 0.1 mg/mL (insoluble) | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.14 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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