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HPPH

Name: HPPH
Brand: TargetMol
SKU: T15501
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15501Cas No. 149402-51-7

Alias Photochlor

HPPH (Photochlor) (Photochlor) is a second-generation photosensitizer. It is used as photodynamic therapy (PDT) agent.

HPPH

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Purity: 99.72%

Catalog No. T15501Alias PhotochlorCas No. 149402-51-7

HPPH (Photochlor) (Photochlor) is a second-generation photosensitizer. It is used as photodynamic therapy (PDT) agent.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$60	In Stock	In Stock
2 mg	$88	In Stock	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$263	In Stock	In Stock
25 mg	$455	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.72%

Appearance:Solid

Color:Black

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	HPPH (Photochlor) (Photochlor) is a second-generation photosensitizer. It is used as photodynamic therapy (PDT) agent.
In vitro	Cells treated with GO-PEG-HHPH displays a stronger fluorescence signal than those treated with free HPPH. In fact, the fluorescence of HPPH is rather weak. After 24 h, Fluorescence image of 4T1 cells incubated with 0.49 μg/mL GO-PEG, 1 μM HPPH (free HPPH), or equivalent amount of GO-PEG-HPPH (1 μM HPPH and 0.49 μg/mL GO-PEG). The cellular uptake of GO-PEG-HPPH and HPPH is investigated with 4T1 murine mammary cancer cells. The cells are incubated with GO-PEG-HPPH and free HPPH at equivalent HPPH concentration (1 μM) for 24 h and then observed with a confocal microscope [1].
In vivo	A combination treatment regimen for Colo26-HA tumor-bearing BALB/c mice involves administering an HPPH-PDT (0.4 μmoles/kg HPPH followed by 665 nm light at 48 J/cm2) to enhance anti-tumor immunity. Following a 9-day rest period and an HPPH injection, tumors receive a control treatment with 665 nm light at 132 J/cm2 on day 10 [2].
Synonyms	Photochlor

Chemical Properties

Molecular Weight	636.82
Formula	C₃₉H₄₈N₄O₄
Cas No.	149402-51-7
Smiles	CCCCCCOC(C)c1c(C)c2\C=C3/N=C([C@@H](CCC(O)=O)[C@@H]3C)C3=C4NC(\C=c5/[nH]\c(=C/c1[nH]2)c(C)c5CC)C(C)=C4C(=O)C3
Relative Density.	1.184 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (78.52 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5703 mL	7.8515 mL	15.7030 mL	78.5151 mL
5 mM	0.3141 mL	1.5703 mL	3.1406 mL	15.7030 mL
10 mM	0.1570 mL	0.7852 mL	1.5703 mL	7.8515 mL
20 mM	0.0785 mL	0.3926 mL	0.7852 mL	3.9258 mL
50 mM	0.0314 mL	0.1570 mL	0.3141 mL	1.5703 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc