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Tisolagiline (KDS2010) is a potent, highly selective and reversible MAO-B inhibitor with IC50=8 nM and oral activity for the treatment of Alzheimer's disease and obesity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $35 | In Stock | |
5 mg | $78 | In Stock | |
10 mg | $125 | In Stock | |
25 mg | $251 | In Stock | |
50 mg | $398 | In Stock | |
100 mg | $642 | In Stock |
Description | Tisolagiline (KDS2010) is a potent, highly selective and reversible MAO-B inhibitor with IC50=8 nM and oral activity for the treatment of Alzheimer's disease and obesity. |
Targets&IC50 | MAO-B:8.0 nM |
In vitro | Tisolagiline demonstrated high potency in inhibiting MAO-B in human cell assays, with an IC₅₀ of 8.0 nM, showing over 1,250-fold selectivity for MAO-B over MAO-A[1]. |
In vivo | In a MPTP-induced Parkinson’s disease mouse model, oral administration of Tisolagiline (10 mg/kg/day for 5 days) significantly protected dopaminergic neurons in the substantia nigra and improved motor function. Furthermore, chronic administration in non-human primates (cynomolgus monkeys) showed favorable pharmacokinetics and safety at doses up to 100 mg/kg/day for 4 weeks, with reversible MAO-B inhibition and no significant adverse effects observed[1]. |
Alias | KDS2010, KDS 2010 |
Molecular Weight | 322.33 |
Formula | C17H17F3N2O |
Cas No. | 1894207-44-3 |
Smiles | C(F)(F)(F)C1=CC=C(C=C1)C2=CC=C(CN[C@H](C(N)=O)C)C=C2 |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80.00 mg/mL (248.19 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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