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Tisolagiline

Name: Tisolagiline
Brand: TargetMol
SKU: T78127
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78127Cas No. 1894207-44-3

Alias KDS2010, KDS 2010

Tisolagiline (KDS2010) is a potent, highly selective and reversible MAO-B inhibitor with IC50=8 nM and oral activity for the treatment of Alzheimer's disease and obesity.

Tisolagiline

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Purity: 99.65%

Catalog No. T78127Alias KDS2010, KDS 2010Cas No. 1894207-44-3

Tisolagiline (KDS2010) is a potent, highly selective and reversible MAO-B inhibitor with IC50=8 nM and oral activity for the treatment of Alzheimer's disease and obesity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$78	In Stock	In Stock
10 mg	$125	In Stock	In Stock
25 mg	$251	In Stock	In Stock
50 mg	$398	In Stock	In Stock
100 mg	$642	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.65%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tisolagiline (KDS2010) is a potent, highly selective and reversible MAO-B inhibitor with IC50=8 nM and oral activity for the treatment of Alzheimer's disease and obesity.
Targets&IC50	MAO-B:8.0 nM
In vitro	Tisolagiline demonstrated high potency in inhibiting MAO-B in human cell assays, with an IC₅₀ of 8.0 nM, showing over 1,250-fold selectivity for MAO-B over MAO-A[1].
In vivo	In a MPTP-induced Parkinson’s disease mouse model, oral administration of Tisolagiline (10 mg/kg/day for 5 days) significantly protected dopaminergic neurons in the substantia nigra and improved motor function. Furthermore, chronic administration in non-human primates (cynomolgus monkeys) showed favorable pharmacokinetics and safety at doses up to 100 mg/kg/day for 4 weeks, with reversible MAO-B inhibition and no significant adverse effects observed[1].
Synonyms	KDS2010, KDS 2010

Chemical Properties

Molecular Weight	322.33
Formula	C₁₇H₁₇F₃N₂O
Cas No.	1894207-44-3
Smiles	C(F)(F)(F)C1=CC=C(C=C1)C2=CC=C(CN[C@H](C(N)=O)C)C=C2

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (248.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (10.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1024 mL	15.5121 mL	31.0241 mL	155.1205 mL
5 mM	0.6205 mL	3.1024 mL	6.2048 mL	31.0241 mL
10 mM	0.3102 mL	1.5512 mL	3.1024 mL	15.5121 mL
20 mM	0.1551 mL	0.7756 mL	1.5512 mL	7.7560 mL
50 mM	0.0620 mL	0.3102 mL	0.6205 mL	3.1024 mL
100 mM	0.0310 mL	0.1551 mL	0.3102 mL	1.5512 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc