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Tisolagiline

🥰Excellent
Catalog No. T78127Cas No. 1894207-44-3
Alias KDS2010, KDS 2010

Tisolagiline (KDS2010) is a potent, highly selective and reversible MAO-B inhibitor with IC50=8 nM and oral activity for the treatment of Alzheimer's disease and obesity.

Tisolagiline

Tisolagiline

🥰Excellent
Catalog No. T78127Alias KDS2010, KDS 2010Cas No. 1894207-44-3
Tisolagiline (KDS2010) is a potent, highly selective and reversible MAO-B inhibitor with IC50=8 nM and oral activity for the treatment of Alzheimer's disease and obesity.
Pack SizePriceAvailabilityQuantity
1 mg$35In Stock
5 mg$78In Stock
10 mg$125In Stock
25 mg$251In Stock
50 mg$398In Stock
100 mg$642In Stock
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Product Introduction

Bioactivity
Description
Tisolagiline (KDS2010) is a potent, highly selective and reversible MAO-B inhibitor with IC50=8 nM and oral activity for the treatment of Alzheimer's disease and obesity.
Targets&IC50
MAO-B:8.0 nM
In vitro
Tisolagiline demonstrated high potency in inhibiting MAO-B in human cell assays, with an IC₅₀ of 8.0 nM, showing over 1,250-fold selectivity for MAO-B over MAO-A[1].
In vivo
In a MPTP-induced Parkinson’s disease mouse model, oral administration of Tisolagiline (10 mg/kg/day for 5 days) significantly protected dopaminergic neurons in the substantia nigra and improved motor function. Furthermore, chronic administration in non-human primates (cynomolgus monkeys) showed favorable pharmacokinetics and safety at doses up to 100 mg/kg/day for 4 weeks, with reversible MAO-B inhibition and no significant adverse effects observed[1].
AliasKDS2010, KDS 2010
Chemical Properties
Molecular Weight322.33
FormulaC17H17F3N2O
Cas No.1894207-44-3
SmilesC(F)(F)(F)C1=CC=C(C=C1)C2=CC=C(CN[C@H](C(N)=O)C)C=C2
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80.00 mg/mL (248.19 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1024 mL15.5121 mL31.0241 mL155.1205 mL
5 mM0.6205 mL3.1024 mL6.2048 mL31.0241 mL
10 mM0.3102 mL1.5512 mL3.1024 mL15.5121 mL
20 mM0.1551 mL0.7756 mL1.5512 mL7.7560 mL
50 mM0.0620 mL0.3102 mL0.6205 mL3.1024 mL
100 mM0.0310 mL0.1551 mL0.3102 mL1.5512 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Dose Conversion

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