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OUL35

Name: OUL35
Brand: TargetMol
SKU: T9024
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9024Cas No. 6336-34-1

Alias NSC39047

OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.

OUL35

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Purity: 99.2%

Catalog No. T9024Alias NSC39047Cas No. 6336-34-1

OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$51	In Stock	In Stock
25 mg	$100	In Stock	In Stock
50 mg	$158	In Stock	In Stock
100 mg	$245	In Stock	In Stock
200 mg	$365	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.2%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

OUL35 AI Summary

OUL35 demonstrates multifaceted bioactivity as an inhibitor across various biochemical assays. It shows notable potency in inhibiting the MLL CXXC domain-DNA interaction, Aldehyde Dehydrogenase 1 (ALDH1A1), and the EPAC1 receptor. Additionally, it functions as a delayed death inhibitor of the malarial parasite plastid and impedes Lassa Virus binding or entry into cells. Significantly, it exhibits inhibitory effects on several PARP enzymes, particularly PARP10, with an IC50 of 645.65 nM, although it has lower potency and poor selectivity against other PARPs like PARP14 and PARP15. The compound effectively inhibits ARTD10 and its R931A mutant with IC50 values of 330.0 nM and 600.0 nM, respectively, while also showing stabilizing effects on the melting temperatures of ARTD family proteins. It also acts as a broad-spectrum antibacterial agent against multiple bacterial strains, although it lacks significant antifungal activity. Furthermore, OUL35 inhibits MARylation of the SRPK2 substrate for PARP10 and PARP11, with IC50 values around 1300 nM. In cellular assays, it exhibits cytoprotective activity by rescuing PARP10-induced cell death in HeLa cells with an IC50 of 1350.0 nM, while also displaying varying inhibitory potencies across different PARPs such as PARP14 and PARP15..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.
Targets&IC50	ARTD10/PARP10:329 nM (IC50)
Synonyms	NSC39047

Chemical Properties

Molecular Weight	256.26
Formula	C₁₄H₁₂N₂O₃
Cas No.	6336-34-1
Smiles	NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1
Relative Density.	1.298 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (214.63 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9023 mL	19.5114 mL	39.0229 mL	195.1143 mL
5 mM	0.7805 mL	3.9023 mL	7.8046 mL	39.0229 mL
10 mM	0.3902 mL	1.9511 mL	3.9023 mL	19.5114 mL
20 mM	0.1951 mL	0.9756 mL	1.9511 mL	9.7557 mL
50 mM	0.0780 mL	0.3902 mL	0.7805 mL	3.9023 mL
100 mM	0.0390 mL	0.1951 mL	0.3902 mL	1.9511 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc