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ET receptor antagonist 1

Catalog No. T79573

ET Receptor Antagonist 1 (compound 16h), with an IC50 value of 0.18 nM, is an orally active agent that can be utilized for pulmonary arterial hypertension (PAH) research. It has demonstrated efficacy in mitigating monocrotaline-induced PAH in a rat model [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

ET receptor antagonist 1 Chemical Structure

ET receptor antagonist 1, CAS N/A

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Biological Description

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Description	ET Receptor Antagonist 1 (compound 16h), with an IC50 value of 0.18 nM, is an orally active agent that can be utilized for pulmonary arterial hypertension (PAH) research. It has demonstrated efficacy in mitigating monocrotaline-induced PAH in a rat model [1].
In vivo	ET receptor antagonist 1 (compound 16h), administered orally at dosages of 150 mg/kg/d and 300 mg/kg/d beginning 48 hours post-MCT treatment for a period of 21-26 days, significantly reduced mean pulmonary arterial pressure (mPAP) levels in rats exposed to MCT, and decreased levels of HIF1α, ANP, and TNNI3, exhibiting antioxidant properties and inhibiting lipid peroxidation [1].

Molecular Weight	459.52
Formula	C21H25N5O5S

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

ET receptor antagonist 1 Endocrinology/Hormones Estrogen Receptor/ERR inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.