PROTAC CDK2/4/6 Degrader-1

Name: PROTAC CDK2/4/6 Degrader-1
Brand: TargetMol
SKU: T217192
Rating: 4.5 (1 reviews)

Catalog No. T217192 Copy Product Info

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PROTACCDK2/4/6 Degrader-1 is an orally active CDK2/CDK4/CDK6 PROTAC degrader. It is a prodrug created through a one-step reaction from PROTACCDK2/4/6 Degrader-2 using chloromethylnorvaline ester. This compound is applicable in research related to malignant melanoma.

PROTAC CDK2/4/6 Degrader-1

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Catalog No. T217192

PROTAC CDK2/4/6 Degrader-1

Cas No. 2541626-55-3

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	PROTACCDK2/4/6 Degrader-1 is an orally active CDK2/CDK4/CDK6 PROTAC degrader. It is a prodrug created through a one-step reaction from PROTACCDK2/4/6 Degrader-2 using chloromethylnorvaline ester. This compound is applicable in research related to malignant melanoma.
In vitro	PROTAC CDK2/4/6 Degrader-1 (compound 11) is a prodrug derived from a one-step reaction of PROTAC CDK2/4/6 Degrader-2 (compound 3) with chloromethyl neopentanoate. PROTAC CDK2/4/6 Degrader-2 is a PROTAC CDK2/4/6 degrader that targets the degradation of CDK 2/4/6 proteins and complexes, inducing cell cycle arrest and apoptosis in melanoma cells.
In vivo	PROTAC CDK2/4/6 Degrader (compound 11), administered orally at a dosage of 200 mg/kg once daily for 15 days, significantly inhibits tumor growth and facilitates the degradation of CDK2/4/6 in the B16F10 xenograft mouse model.

Chemical Properties

Molecular Weight	862
Formula	C₄₆H₅₅N₉O₈
Cas No.	2541626-55-3
Smiles	O=C(NCCCCCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)N(C(=O)CC3)COC(=O)C(C)(C)C)C4=CC=C(C=C4)NC=5N=CC=6C=C(C(=O)N(C)C)N(C6N5)C7CCCC7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc