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Tiaprofenic acid

Name: Tiaprofenic acid
Brand: TargetMol
SKU: T4561
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4561Cas No. 33005-95-7

Alias Tiaprofensaeure, Surgam, Acido tiaprofenico

Tiaprofenic acid (Acido tiaprofenico) is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.

Tiaprofenic acid

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Purity: 99.51%

Catalog No. T4561Alias Tiaprofensaeure, Surgam, Acido tiaprofenicoCas No. 33005-95-7

Tiaprofenic acid (Acido tiaprofenico) is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$34	In Stock	In Stock
25 mg	$56	In Stock	In Stock
50 mg	$83	In Stock	In Stock
100 mg	$119	In Stock	In Stock
200 mg	$178	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.51%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Tiaprofenic acid AI Summary

Tiaprofenic acid exhibits a wide range of bioactivities and pharmacological properties. It inhibits CXCL8-induced chemotaxis of human polymorphonuclear cells by 7.0% at a concentration of 10e-8 M and shows substantial inhibition (>99.0%) of lipopolysaccharide-induced PGE-2 production at 10e-5 M. The compound induces genotoxicity in human embryonic kidney cells expressing luciferase-tagged ELG1, inhibits Histone Lysine Methyltransferase G9a and ELG1-dependent DNA repair, and affects HP1-beta Chromodomain Interactions with Methylated Histone Tails. It counters TGF-b cytotoxicity and inhibits firefly luciferase, leading to DNA re-replication in normal breast and colon adenocarcinoma cells. Furthermore, it acts as an inverse agonist of the GLP-1 receptor and activates BRCA1 expression. Tiaprofenic acid inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) and blocks the entry of Ebola Virus, exhibiting antiviral activity against Foot and Mouth Disease Virus and SARS-CoV-2. In permeability studies, Tiaprofenic acid crossed the human Caco2 cell membrane with a logPapp value of -4.41, indicating its membrane permeability. It selectively exhibits activity in the UGT2B7 enzyme but not in UGT2B10 and UGT2B4. In clinical trials, it was found to have moderate liver toxicity, with a hepatotoxicity rate of 3.8%, though no severe or chronic liver conditions were observed. Against SARS-CoV-2, Tiaprofenic acid showed a low inhibition index of 0.07411 in Vero E6 cells and moderate potency with an IC50 value greater than 19952.62 nM in HRCE cells. The compound also inhibits the N-terminal His6-tagged recombinant human UCHL5 enzyme with 15.0% inhibition at 200 uM and an IC50 of 2946000.0 nM and shows 41.58% inhibition of human HDAC6 activity using a commercial peptide substrate but a -5.97% inhibition with a custom peptide substrate, suggesting substrate-dependent bioactivity. The compound's interactions extend to various human and rat receptors and enzymes, including binding affinities to ADRB2, DRD3, AVPR1A, and CNR1, and exhibiting agonist or antagonist activities at CHRM2, HTR2A, and ADRA1A. It also inhibits targets like PTGS1 and MAOA, demonstrating potency across these bioactivities with AC50 values ranging from nanomolar to micromolar concentrations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tiaprofenic acid (Acido tiaprofenico) is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.
Synonyms	Tiaprofensaeure, Surgam, Acido tiaprofenico

Chemical Properties

Molecular Weight	260.31
Formula	C₁₄H₁₂O₃S
Cas No.	33005-95-7
Smiles	CC(C(O)=O)c1ccc(s1)C(=O)c1ccccc1
Relative Density.	1.2959 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

Ethanol: 30 mg/mL (115.25 mM), Sonication is recommended.

DMSO: 60 mg/mL (230.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8416 mL	19.2079 mL	38.4157 mL	192.0787 mL
5 mM	0.7683 mL	3.8416 mL	7.6831 mL	38.4157 mL
10 mM	0.3842 mL	1.9208 mL	3.8416 mL	19.2079 mL
20 mM	0.1921 mL	0.9604 mL	1.9208 mL	9.6039 mL
50 mM	0.0768 mL	0.3842 mL	0.7683 mL	3.8416 mL
100 mM	0.0384 mL	0.1921 mL	0.3842 mL	1.9208 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc