Immobilized Human TNFR1, His Tag at 0.5 μg/ml (100 μl/Well). Dose response curve for Biotinylated Human TNF alpha, His Tag with the EC50 of 16.5 ng/ml determined by ELISA.

TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P19438-1.

Human

HEK293 Cells

Leu30-Thr211

> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenuate the cell death and inflammation associated with TNF-α, while sparing or potentiating the protective effects of TNFR2 signalling.