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ML251

Name: ML251
Brand: TargetMol
SKU: T64320
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T64320Cas No. 1486482-16-9

ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase[1]. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1].

ML251

🥰Excellent

Purity: 99.87%

Catalog No. T64320Cas No. 1486482-16-9

Pack Size	Price	Availability
1 mg	$117	In Stock
5 mg	$289	In Stock
10 mg	$455	In Stock
25 mg	$753	In Stock
50 mg	$1,060	In Stock
100 mg	$1,430	In Stock
200 mg	$1,920	In Stock
1 mL x 10 mM (in DMSO)	$317	In Stock

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Batch Information

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Purity:99.87%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase[1]. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1].
Targets&IC50	PFK (T. cruzi):0.13 μM, PFK (T. b. brucei):0.37 μM
In vitro	ML251 produces modest dose-dependent toxicity[1].
Cell Research	The cell cytotoxicity assay of ML251 (0~33.3 μg/mL) in T. brucei cell shows dose-dependent reduction of cell viability[1].

Chemical Properties

Molecular Weight	426.27
Formula	C₁₇H₁₃Cl₂N₃O₄S
Cas No.	1486482-16-9
Smiles	Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2ccon2)cc1Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (117.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3459 mL	11.7297 mL	23.4593 mL	117.2965 mL
5 mM	0.4692 mL	2.3459 mL	4.6919 mL	23.4593 mL
10 mM	0.2346 mL	1.1730 mL	2.3459 mL	11.7297 mL
20 mM	0.1173 mL	0.5865 mL	1.1730 mL	5.8648 mL
50 mM	0.0469 mL	0.2346 mL	0.4692 mL	2.3459 mL
100 mM	0.0235 mL	0.1173 mL	0.2346 mL	1.1730 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc