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MAFP

Name: MAFP
Brand: TargetMol
SKU: T15948
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15948Cas No. 188404-10-6

Alias Methyl Arachidonyl Fluorophosphonate

MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective, active-site directed irreversible inhibitor of anandamide amidase, cPLA2, and iPLA2.

MAFP

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Catalog No. T15948Alias Methyl Arachidonyl FluorophosphonateCas No. 188404-10-6

MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective, active-site directed irreversible inhibitor of anandamide amidase, cPLA2, and iPLA2.

Pack Size	Price	USA Warehouse	Global Warehouse
1mg (26.99mM*100ul in methyl acetate)	$68	-	In Stock
5mg (26.99mM*500ul in methyl acetate)	$240	-	In Stock
10mg (26.99mM*1ml in methyl acetate)	$360	-	In Stock
25mg (26.99mM*2500ul in methyl acetate)	$595	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Appearance:Liquid

Color:Transparent to Yellow

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COA

Product Introduction

Bioactivity

Description	MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective, active-site directed irreversible inhibitor of anandamide amidase, cPLA2, and iPLA2.
In vitro	In a concentration-dependent manner after a 5 min preincubation at 40°C in P388D1 cells, MAFP inhibits iPLA2 (IC50: 5 μM). MAFP is also an inhibitor of anandamide amidase and as a ligand for the CB1 cannabinoid receptor. MAFP shows selectivity towards anandamide amidase for which it is approximately 3000 and 30000-fold more potent than it is towards chymotrypsin and trypsin, respectively. cPLA is a phospholipid hydrolase using the hydroxyl of serine-228 residue as its catalytic nucleophile[1]. MAFP displaces [3H]CP-55940 binding to the CB1 cannabinoid receptor with an IC50 of 20 nM vs 40 nM for anandamide[2].
Synonyms	Methyl Arachidonyl Fluorophosphonate

Chemical Properties

Molecular Weight	370.48
Formula	C₂₁H₃₆FO₂P
Cas No.	188404-10-6
Smiles	C(/C=C\C/C=C\C/C=C\C/C=C\CCCCC)CCCP(OC)(F)=O
Relative Density.	0.960 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methyl Acetate: 9 mg/mL (24.29 mM), Sonication is recommended.

DMSO: 90 mg/mL (242.93 mM), Sonication is recommended.

Solution Preparation Table

Methyl Acetate/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6992 mL	13.4960 mL	26.9920 mL	134.9601 mL
5 mM	0.5398 mL	2.6992 mL	5.3984 mL	26.9920 mL
10 mM	0.2699 mL	1.3496 mL	2.6992 mL	13.4960 mL
20 mM	0.1350 mL	0.6748 mL	1.3496 mL	6.7480 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0540 mL	0.2699 mL	0.5398 mL	2.6992 mL
100 mM	0.0270 mL	0.1350 mL	0.2699 mL	1.3496 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc