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Ginkgolide J

Name: Ginkgolide J
Brand: TargetMol
SKU: T6S2115
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S2115Cas No. 107438-79-9

Alias BN 52024, 7-beta-Hydroxyginkgolide A

Ginkgolide J (BN 52024) has neuroprotective activity, it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices.

Ginkgolide J

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Purity: 99.94%

Catalog No. T6S2115Alias BN 52024, 7-beta-Hydroxyginkgolide ACas No. 107438-79-9

Ginkgolide J (BN 52024) has neuroprotective activity, it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$55	In Stock	In Stock
5 mg	$132	In Stock	In Stock
10 mg	$195	In Stock	In Stock
25 mg	$329	In Stock	In Stock
50 mg	$473	In Stock	In Stock
100 mg	$648	-	In Stock
200 mg	$873	-	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Ginkgolide J (BN 52024) has neuroprotective activity, it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices.
In vitro	A new Ginkgo biloba extract P8A (TTL), 70% enriched with terpene trilactones, prevents A beta induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices. This neuroprotective effect is attributed in large part to Ginkgolide J that completely replicates the effect of the extract. Ginkgolide J is also capable of inhibiting cell death of rodent hippocampal neurons caused by A beta[1].
Cell Research	Hippocampal cultures were treated by adding 10 μM Aβ1-42 in its oligomeric form with or without P8A, or alternatively with and without each of the individual ginkgolides and bilobalide (GA, GB, GC GJ, BB).??these compounds were dissolved in DMSO and added to the culture medium at a ratio of 1:1000 (v/v), yielding a 0.1% DMSO solution.?After 24 hrs the number of viable cells was assessed by nuclear counting.?In a separate set of experiments, viable cells were counted by using the ethidium homodimer/calcein-AM combination of vital dyes (LIVE/DEAD Viability/Cytotoxicity Kit for mammalian cells;?Invitrogen), according to the manufacturer instructions.?Values represent the mean SEM of three consecutive experiments.?Each experiment was performed in triplicate[1].
Synonyms	BN 52024, 7-beta-Hydroxyginkgolide A

Chemical Properties

Molecular Weight	424.40
Formula	C₂₀H₂₄O₁₀
Cas No.	107438-79-9
Smiles	[H][C@]12C[C@]34[C@]5([H])OC(=O)C3(O[C@]3([H])OC(=O)[C@H](O)C43[C@@H]([C@H]5O)C(C)(C)C)[C@@]1(O)[C@H](C)C(=O)O2
Relative Density.	1.64 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60.00 mg/mL (141.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (4.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3563 mL	11.7813 mL	23.5627 mL	117.8134 mL
5 mM	0.4713 mL	2.3563 mL	4.7125 mL	23.5627 mL
10 mM	0.2356 mL	1.1781 mL	2.3563 mL	11.7813 mL
20 mM	0.1178 mL	0.5891 mL	1.1781 mL	5.8907 mL
50 mM	0.0471 mL	0.2356 mL	0.4713 mL	2.3563 mL
100 mM	0.0236 mL	0.1178 mL	0.2356 mL	1.1781 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc